/**
 * =============================================================================
 * STYLES.CSS — Base globale du site iCovell
 * =============================================================================
 *
 * Fichier chargé en premier. Définit : variables de couleurs/ombres/bordures,
 * reset, body, .main-content, navbar, footer, sections, cartes, boutons, etc.
 *
 * ORGANISATION DU SITE (où modifier quoi) :
 * - Textes FR/EN        → translations.js (clés utilisées dans data-translate)
 * - Logique (langue,    → script.js (changeLanguage, popups, formulaire, etc.)
 *   popups, formulaire)
 * - Structure des pages → *.html (index, sepsis, drepanocytose, technologies,
 *   recherche, a-propos, contact, projets)
 * - Apparence globale   → styles*.css (base, home, unified, harmony, sepsis, drepano)
 *
 * MODIFIER EN TANT QUE NON-DEVELOPPEUR :
 * - Couleurs : éditer les variables dans :root (--primary-color, --red-primary, etc.).
 * - Police / taille de base : body (font-family, font-size) et variables --radius-*.
 * - Navbar / footer : chercher .navbar, .nav-menu, .footer.
 * - Sections pleine page : .section (min-height, overflow).
 *
 * Ordre de chargement typique : styles.css → styles-home.css → styles-unified.css
 * → styles-harmony.css → styles-sepsis.css / styles-drepanocytose.css (selon page).
 * =============================================================================
 */

/* ---------- Variables CSS — charte graphique bleu / rouge ---------- */
:root {
    /* Couleurs principales - Bleu et Rouge */
    --primary-color: #2c5f8d;
    --primary-dark: #1e4263;
    --primary-light: #3d7bb3;
    --secondary-color: #4a90a4;
    --accent-color: #2c5f8d;
    
    /* Couleurs rouges */
    --red-primary: #c41e3a;
    --red-dark: #9a1629;
    --red-light: #e63950;
    --red-accent: #ff6b6b;
    
    /* Couleurs de fond - Blanc épuré avec variations */
    --background-light: #ffffff;
    --background-white: #ffffff;
    --background-subtle: #f8f9fa;
    --background-blue: linear-gradient(135deg, rgba(44, 95, 141, 0.03) 0%, rgba(44, 95, 141, 0.08) 100%);
    --background-red: linear-gradient(135deg, rgba(196, 30, 58, 0.03) 0%, rgba(196, 30, 58, 0.08) 100%);
    
    /* Couleurs de texte - Gris scientifique */
    --text-dark: #1a1a1a;
    --text-medium: #4a4a4a;
    --text-light: #666666;
    
    /* Bordures - Subtiles avec couleurs */
    --border-color: #e5e5e5;
    --border-light: #f0f0f0;
    --border-blue: rgba(44, 95, 141, 0.2);
    --border-red: rgba(196, 30, 58, 0.2);
    
    /* Ombres - Enrichies avec couleurs */
    --shadow: 0 4px 12px rgba(44, 95, 141, 0.1), 0 2px 4px rgba(0, 0, 0, 0.05);
    --shadow-medium: 0 6px 20px rgba(44, 95, 141, 0.15), 0 3px 8px rgba(0, 0, 0, 0.08);
    --shadow-hover: 0 8px 28px rgba(44, 95, 141, 0.2), 0 4px 12px rgba(0, 0, 0, 0.1);
    --shadow-red: 0 4px 12px rgba(196, 30, 58, 0.1), 0 2px 4px rgba(0, 0, 0, 0.05);
    --shadow-red-medium: 0 6px 20px rgba(196, 30, 58, 0.15), 0 3px 8px rgba(0, 0, 0, 0.08);
    
    /* Transitions - Douces */
    --transition: all 0.3s cubic-bezier(0.4, 0, 0.2, 1);
    --transition-fast: all 0.2s ease;
    
    /* Angles arrondis - Modernes et uniformes */
    --radius-sm: 12px;
    --radius-md: 16px;
    --radius-lg: 20px;
    --radius-xl: 24px;
    --radius-2xl: 32px;
    --radius-full: 9999px;
    
    /* Dégradés */
    --gradient-blue: linear-gradient(135deg, #2c5f8d 0%, #1e4263 100%);
    --gradient-red: linear-gradient(135deg, #c41e3a 0%, #9a1629 100%);
    --gradient-blue-light: linear-gradient(135deg, rgba(44, 95, 141, 0.05) 0%, rgba(44, 95, 141, 0.1) 100%);
    --gradient-red-light: linear-gradient(135deg, rgba(196, 30, 58, 0.05) 0%, rgba(196, 30, 58, 0.1) 100%);
}

/* ---------- Reset et styles de base ---------- */
* {
    margin: 0;
    padding: 0;
    box-sizing: border-box;
}

body {
    font-family: 'Segoe UI', Tahoma, Geneva, Verdana, sans-serif;
    color: var(--text-dark);
    background-color: var(--background-light);
    line-height: 1.6;
    overflow-x: hidden;
    position: relative;
    padding-top: 0;
}

.main-content {
    padding-top: 80px;
}

@media (max-width: 768px) {
    .main-content {
        /* Padding-top ajusté pour la navbar verticale sur mobile */
        padding-top: 250px;
        transition: padding-top 0.3s ease;
    }
    
    /* Quand navbar est masquée */
    body.navbar-collapsed .main-content {
        padding-top: 35px !important;
    }
}

@media (max-width: 480px) {
    .main-content {
        padding-top: 280px;
        transition: padding-top 0.3s ease;
    }
    
    body.navbar-collapsed .main-content {
        padding-top: 35px !important;
    }
}

/* Bulles de sang animées en arrière-plan */
.blood-bubbles {
    position: fixed;
    top: 0;
    left: 0;
    width: 100%;
    height: 100%;
    z-index: -1;
    overflow: hidden;
    pointer-events: none;
}

.blood-bubble {
    position: absolute;
    border-radius: 50%;
    background: radial-gradient(circle, rgba(196, 30, 58, 0.15) 0%, rgba(154, 22, 41, 0.08) 50%, transparent 100%);
    opacity: 0;
}

/* Variantes de rouge pour les bulles */
.blood-bubble:nth-child(1) {
    width: 80px;
    height: 80px;
    left: 10%;
    animation-delay: 0s;
    background: radial-gradient(circle, rgba(196, 30, 58, 0.2) 0%, rgba(154, 22, 41, 0.1) 50%, transparent 100%);
}

.blood-bubble:nth-child(2) {
    width: 120px;
    height: 120px;
    left: 20%;
    animation-delay: 2s;
    background: radial-gradient(circle, rgba(230, 57, 80, 0.15) 0%, rgba(196, 30, 58, 0.08) 50%, transparent 100%);
}

.blood-bubble:nth-child(3) {
    width: 60px;
    height: 60px;
    left: 30%;
    animation-delay: 4s;
    background: radial-gradient(circle, rgba(154, 22, 41, 0.18) 0%, rgba(122, 18, 33, 0.09) 50%, transparent 100%);
}

.blood-bubble:nth-child(4) {
    width: 100px;
    height: 100px;
    left: 40%;
    animation-delay: 1s;
    background: radial-gradient(circle, rgba(196, 30, 58, 0.16) 0%, rgba(154, 22, 41, 0.08) 50%, transparent 100%);
}

.blood-bubble:nth-child(5) {
    width: 70px;
    height: 70px;
    left: 50%;
    animation-delay: 3s;
    background: radial-gradient(circle, rgba(230, 57, 80, 0.17) 0%, rgba(196, 30, 58, 0.09) 50%, transparent 100%);
}

.blood-bubble:nth-child(6) {
    width: 90px;
    height: 90px;
    left: 60%;
    animation-delay: 5s;
    background: radial-gradient(circle, rgba(154, 22, 41, 0.19) 0%, rgba(122, 18, 33, 0.1) 50%, transparent 100%);
}

.blood-bubble:nth-child(7) {
    width: 110px;
    height: 110px;
    left: 70%;
    animation-delay: 2.5s;
    background: radial-gradient(circle, rgba(196, 30, 58, 0.18) 0%, rgba(154, 22, 41, 0.09) 50%, transparent 100%);
}

.blood-bubble:nth-child(8) {
    width: 65px;
    height: 65px;
    left: 80%;
    animation-delay: 4.5s;
    background: radial-gradient(circle, rgba(230, 57, 80, 0.16) 0%, rgba(196, 30, 58, 0.08) 50%, transparent 100%);
}

.blood-bubble:nth-child(9) {
    width: 85px;
    height: 85px;
    left: 15%;
    animation-delay: 6s;
    background: radial-gradient(circle, rgba(154, 22, 41, 0.17) 0%, rgba(122, 18, 33, 0.09) 50%, transparent 100%);
}

.blood-bubble:nth-child(10) {
    width: 95px;
    height: 95px;
    left: 25%;
    animation-delay: 1.5s;
    background: radial-gradient(circle, rgba(196, 30, 58, 0.15) 0%, rgba(154, 22, 41, 0.08) 50%, transparent 100%);
}

.blood-bubble:nth-child(11) {
    width: 75px;
    height: 75px;
    left: 55%;
    animation-delay: 3.5s;
    background: radial-gradient(circle, rgba(230, 57, 80, 0.18) 0%, rgba(196, 30, 58, 0.09) 50%, transparent 100%);
}

.blood-bubble:nth-child(12) {
    width: 105px;
    height: 105px;
    left: 65%;
    animation-delay: 5.5s;
    background: radial-gradient(circle, rgba(154, 22, 41, 0.16) 0%, rgba(122, 18, 33, 0.08) 50%, transparent 100%);
}

.blood-bubble:nth-child(13) {
    width: 55px;
    height: 55px;
    left: 75%;
    animation-delay: 2s;
    background: radial-gradient(circle, rgba(196, 30, 58, 0.2) 0%, rgba(154, 22, 41, 0.1) 50%, transparent 100%);
}

.blood-bubble:nth-child(14) {
    width: 115px;
    height: 115px;
    left: 85%;
    animation-delay: 4s;
    background: radial-gradient(circle, rgba(230, 57, 80, 0.15) 0%, rgba(196, 30, 58, 0.08) 50%, transparent 100%);
}

.blood-bubble:nth-child(15) {
    width: 50px;
    height: 50px;
    left: 5%;
    animation-delay: 6.5s;
    background: radial-gradient(circle, rgba(154, 22, 41, 0.19) 0%, rgba(122, 18, 33, 0.1) 50%, transparent 100%);
}

@keyframes floatBubble {
    0% {
        transform: translateY(100vh) translateX(0) scale(0) rotate(0deg);
        opacity: 0;
    }
    10% {
        opacity: 0.6;
        transform: translateY(90vh) translateX(10px) scale(0.5) rotate(45deg);
    }
    30% {
        opacity: 0.8;
        transform: translateY(70vh) translateX(20px) scale(0.8) rotate(90deg);
    }
    50% {
        opacity: 0.9;
        transform: translateY(50vh) translateX(30px) scale(1) rotate(135deg);
    }
    70% {
        opacity: 0.8;
        transform: translateY(30vh) translateX(20px) scale(0.9) rotate(180deg);
    }
    90% {
        opacity: 0.5;
        transform: translateY(10vh) translateX(-10px) scale(0.7) rotate(225deg);
    }
    100% {
        transform: translateY(-10vh) translateX(-30px) scale(0.5) rotate(270deg);
        opacity: 0;
    }
}

/* Animation alternative pour certaines bulles */
.blood-bubble:nth-child(odd) {
    animation-name: floatBubbleReverse;
    animation-duration: 25s;
}

@keyframes floatBubbleReverse {
    0% {
        transform: translateY(100vh) translateX(0) scale(0) rotate(0deg);
        opacity: 0;
    }
    10% {
        opacity: 0.6;
        transform: translateY(90vh) translateX(-15px) scale(0.5) rotate(-45deg);
    }
    30% {
        opacity: 0.8;
        transform: translateY(70vh) translateX(-25px) scale(0.8) rotate(-90deg);
    }
    50% {
        opacity: 0.9;
        transform: translateY(50vh) translateX(-35px) scale(1) rotate(-135deg);
    }
    70% {
        opacity: 0.8;
        transform: translateY(30vh) translateX(-25px) scale(0.9) rotate(-180deg);
    }
    90% {
        opacity: 0.5;
        transform: translateY(10vh) translateX(10px) scale(0.7) rotate(-225deg);
    }
    100% {
        transform: translateY(-10vh) translateX(30px) scale(0.5) rotate(-270deg);
        opacity: 0;
    }
}

/* Bandeau de navigation - Design moderne et esthétique */
.navbar {
    position: fixed !important;
    top: 0 !important;
    left: 0 !important;
    right: 0 !important;
    background: rgba(255, 255, 255, 0.98);
    backdrop-filter: blur(10px);
    -webkit-backdrop-filter: blur(10px);
    box-shadow: 0 2px 20px rgba(0, 0, 0, 0.08);
    z-index: 1000 !important;
    padding: 0;
    transition: all 0.3s cubic-bezier(0.4, 0, 0.2, 1);
    border-bottom: 1px solid rgba(0, 0, 0, 0.05);
    pointer-events: auto;
    width: 100% !important;
    margin: 0 !important;
}

.navbar.scrolled {
    padding: 0;
    box-shadow: 0 2px 15px rgba(0, 0, 0, 0.1);
}

    .navbar.scrolled .nav-container {
        padding: 0.7rem 2rem;
        min-height: 65px;
    }
    
    @media (max-width: 768px) {
        .navbar.scrolled .nav-container {
            padding: 0.25rem 1.5rem;
            min-height: 28px;
        }
        
        .navbar.scrolled .logo {
            font-size: 1.1rem;
        }
        
        .navbar.scrolled .logo-image {
            height: 45px !important;
            max-height: 45px !important;
            max-width: 190px !important;
        }
    }
    
    @media (max-width: 480px) {
        .navbar.scrolled .nav-container {
            padding: 0.2rem 1rem;
            min-height: 25px;
        }
        
        .navbar.scrolled .logo {
            font-size: 1rem;
        }
        
        .navbar.scrolled .logo-image {
            height: 45px !important;
            max-height: 45px !important;
            max-width: 190px !important;
        }
    }

.navbar:hover {
    box-shadow: 0 4px 30px rgba(0, 0, 0, 0.12);
}

/* Bouton hamburger pour mobile */
.hamburger-menu {
    display: none;
    flex-direction: column;
    justify-content: space-around;
    width: 30px;
    height: 30px;
    background: transparent;
    border: none;
    cursor: pointer;
    padding: 0;
    z-index: 1002;
    position: relative;
    pointer-events: auto;
    touch-action: manipulation;
    -webkit-tap-highlight-color: rgba(0, 0, 0, 0.1);
}

.hamburger-menu span {
    display: block;
    height: 3px;
    width: 100%;
    background: var(--primary-color);
    border-radius: 12px;
    transition: all 0.3s ease;
}

.hamburger-menu span {
    background: #2c5f8d;
}

.hamburger-menu.active span:nth-child(1) {
    transform: rotate(45deg) translate(8px, 8px);
}

.hamburger-menu.active span:nth-child(2) {
    opacity: 0;
}

.hamburger-menu.active span:nth-child(3) {
    transform: rotate(-45deg) translate(7px, -7px);
}

.nav-container {
    max-width: 1400px;
    margin: 0 auto;
    display: flex;
    align-items: center;
    justify-content: space-between;
    padding: 0.8rem 2rem;
    gap: 0.5rem;
    transition: padding 0.3s ease;
    min-height: 70px;
    box-sizing: border-box;
}

/* Logo - Design moderne */
.logo-container {
    display: flex;
    align-items: center;
    flex-shrink: 0;
    height: fit-content;
    max-height: 50px;
}

.logo-link {
    display: flex;
    align-items: center;
    gap: 0.1rem;
    text-decoration: none;
    height: fit-content;
    max-height: 50px;
    margin-right: 0.5rem;
}

.logo-image {
    height: 50px !important;
    max-height: 50px !important;
    width: auto !important;
    max-width: 200px !important;
    object-fit: contain !important;
    display: block !important;
    flex-shrink: 0 !important;
}

.logo {
    font-size: 1.4rem;
    font-weight: 700;
    color: var(--primary-color);
    letter-spacing: 0.5px;
    position: relative;
    transition: all 0.3s cubic-bezier(0.4, 0, 0.2, 1);
    cursor: pointer;
    text-decoration: none;
    background: linear-gradient(135deg, var(--primary-color) 0%, var(--primary-dark) 100%);
    -webkit-background-clip: text;
    -webkit-text-fill-color: transparent;
    background-clip: text;
    line-height: 1;
}

/* Logo en bleu pour toutes les pages */
.logo {
    background: linear-gradient(135deg, #2c5f8d 0%, #1e4263 100%);
    -webkit-background-clip: text;
    -webkit-text-fill-color: transparent;
    background-clip: text;
}

.logo::after {
    content: '';
    position: absolute;
    bottom: -3px;
    left: 0;
    width: 0;
    height: 3px;
    background: linear-gradient(90deg, var(--primary-color) 0%, var(--primary-dark) 100%);
    transition: width 0.4s cubic-bezier(0.4, 0, 0.2, 1);
    border-radius: 8px;
}

/* Ligne sous le logo en bleu pour toutes les pages */
.logo::after {
    background: linear-gradient(90deg, #2c5f8d 0%, #1e4263 100%);
}

.logo:hover::after {
    width: 100%;
}

.logo:hover {
    transform: translateY(-2px);
    filter: brightness(1.1);
}

/* Menu de navigation - Design moderne */
.nav-menu {
    display: flex;
    align-items: center;
    gap: 0.5rem;
    flex: 1;
    justify-content: center;
    transition: all 0.3s ease;
    visibility: visible !important;
    opacity: 1 !important;
}

/* S'assurer que tous les liens sont accessibles */
.nav-menu a,
.nav-menu .nav-link {
    display: inline-block;
    visibility: visible !important;
    opacity: 1 !important;
    pointer-events: auto !important;
    cursor: pointer !important;
    text-decoration: none;
}

/* Navigation responsive - Accessible sur toutes les tailles */
@media (max-width: 768px) {
    /* Navbar avec possibilité de masquer/afficher */
    .navbar {
        position: fixed !important;
        top: 0 !important;
        left: 0 !important;
        right: 0 !important;
        width: 100% !important;
        z-index: 1000 !important;
        margin: 0 !important;
        transform: translateY(calc(-100% + 35px)) !important;
        transition: transform 0.3s ease !important;
    }
    
    .navbar.expanded {
        transform: translateY(0) !important;
    }
    
    .navbar.collapsed {
        transform: translateY(calc(-100% + 35px)) !important;
    }
    
    /* Ajuster le padding-top quand navbar est masquée */
    .navbar.collapsed ~ .main-content,
    body:has(.navbar.collapsed) .main-content {
        padding-top: 35px !important;
    }
    
    .nav-container {
        flex-direction: column;
        padding: 0.5rem;
        gap: 0.5rem;
        align-items: stretch;
        position: relative;
        min-height: auto;
    }
    
    .logo {
        font-size: 1.2rem;
        text-align: center;
    }
    
    .logo-image {
        height: 45px !important;
        max-height: 45px !important;
        max-width: 190px !important;
    }
    
    /* Cacher hamburger */
    .hamburger-menu {
        display: none !important;
    }
    
    /* Bouton toggle navbar avec flèche */
    .navbar-toggle {
        position: absolute;
        bottom: -35px;
        left: 50%;
        transform: translateX(-50%);
        width: 60px;
        height: 35px;
        background: rgba(255, 255, 255, 0.98);
        border: none;
        border-bottom: 1px solid rgba(0, 0, 0, 0.1);
        border-left: 1px solid rgba(0, 0, 0, 0.1);
        border-right: 1px solid rgba(0, 0, 0, 0.1);
        border-radius: 0 0 20px 20px;
        cursor: pointer;
        display: flex;
        align-items: center;
        justify-content: center;
        box-shadow: 0 4px 10px rgba(0, 0, 0, 0.1);
        z-index: 1001;
        padding: 0;
        transition: all 0.3s ease;
    }
    
    .navbar-toggle:hover {
        background: rgba(255, 255, 255, 1);
        box-shadow: 0 6px 15px rgba(0, 0, 0, 0.15);
    }
    
    /* Flèche supprimée pour un design épuré */
    
    /* Menu navigation - Masquable */
    .nav-menu {
        display: flex !important;
        flex-direction: column;
        width: 100%;
        gap: 0.5rem;
        order: 2;
        visibility: visible !important;
        opacity: 0 !important;
        max-height: 0;
        overflow: hidden;
        transition: max-height 0.3s ease, opacity 0.3s ease;
    }
    
    .navbar.expanded .nav-menu {
        opacity: 1 !important;
        max-height: 500px;
    }
    
    .navbar.collapsed .nav-menu {
        max-height: 0;
        opacity: 0;
        overflow: hidden;
    }
    
    .language-switcher {
        transition: opacity 0.3s ease, max-height 0.3s ease;
        opacity: 0;
        max-height: 0;
        overflow: hidden;
    }
    
    .navbar.expanded .language-switcher {
        opacity: 1;
        max-height: 100px;
    }
    
    .navbar.collapsed .language-switcher {
        opacity: 0;
        max-height: 0;
        overflow: hidden;
        padding: 0;
        margin: 0;
    }
    
    /* Boutons de navigation - TOUJOURS ACCESSIBLES */
    .nav-link {
        display: block !important;
        width: 100% !important;
        padding: 1rem !important;
        text-align: center !important;
        font-size: 1rem !important;
        border-radius: 8px !important;
        background: #f5f5f5 !important;
        color: #333 !important;
        text-decoration: none !important;
        font-weight: 500 !important;
        transition: all 0.2s !important;
        cursor: pointer !important;
        pointer-events: auto !important;
        visibility: visible !important;
        opacity: 1 !important;
    }
    
    .nav-link:hover {
        background: #e0e0e0 !important;
        color: var(--primary-color) !important;
    }
    
    .nav-link:hover {
        color: #2c5f8d !important;
    }
    
    .nav-link.active {
        background: #2c5f8d !important;
        color: white !important;
        font-weight: 600 !important;
    }
    
    /* Sélecteur de langue */
    .language-switcher {
        display: flex !important;
        justify-content: center;
        order: 3;
        width: 100%;
        padding: 0.5rem;
        visibility: visible !important;
    }
    
    .language-switcher .lang-btn {
        padding: 0.6rem 1.2rem;
        font-size: 0.9rem;
        cursor: pointer !important;
        pointer-events: auto !important;
    }
}

@media (max-width: 480px) {
    .nav-container {
        padding: 0.8rem;
    }
    
    .logo {
        font-size: 1.1rem;
    }
    
    .logo-image {
        height: 40px !important;
        max-height: 40px !important;
        max-width: 180px !important;
    }
    
    .nav-link {
        padding: 0.9rem;
        font-size: 1.05rem;
    }
    
    .language-switcher .lang-btn {
        padding: 0.5rem 1rem;
        font-size: 0.85rem;
    }
}

.nav-link {
    text-decoration: none;
    color: #1a1a1a;
    font-weight: 500;
    padding: 0.5rem 1.2rem;
    border-radius: 16px;
    transition: all 0.3s cubic-bezier(0.4, 0, 0.2, 1);
    position: relative;
    background: none;
    border: none;
    cursor: pointer;
    font-size: 1.05rem;
    font-family: inherit;
    white-space: nowrap;
    overflow: hidden;
    line-height: 1.2;
}

/* Menu mobile - override styles globaux */
@media (max-width: 768px) {
    .nav-menu a::before,
    .nav-menu a::after {
        display: none;
    }
}


.nav-link::before {
    content: '';
    position: absolute;
    bottom: 0;
    left: 50%;
    transform: translateX(-50%);
    width: 0;
    height: 3px;
    background: linear-gradient(90deg, #2c5f8d 0%, #1e4263 100%);
    transition: width 0.4s cubic-bezier(0.4, 0, 0.2, 1);
    border-radius: 2px 2px 0 0;
}

.nav-link::after {
    content: '';
    position: absolute;
    top: 0;
    left: 0;
    right: 0;
    bottom: 0;
    background: linear-gradient(135deg, rgba(44, 95, 141, 0.05) 0%, rgba(44, 95, 141, 0.02) 100%);
    opacity: 0;
    transition: opacity 0.3s ease;
    border-radius: 20px;
}

.nav-link:hover::after {
    opacity: 1;
}

.nav-link:hover::before,
.nav-link.active::before {
    width: 70%;
}

.nav-link:hover {
    color: #2c5f8d;
    transform: translateY(-2px);
}

.nav-link.active {
    color: #2c5f8d;
    font-weight: 600;
}

.nav-link.active::after {
    opacity: 1;
    background: linear-gradient(135deg, rgba(44, 95, 141, 0.1) 0%, rgba(44, 95, 141, 0.05) 100%);
}

/* Menu déroulant */
.dropdown {
    position: relative;
}

.dropdown-btn {
    display: flex;
    align-items: center;
    gap: 0.5rem;
}

/* Flèche supprimée pour un design épuré */

.dropdown-content {
    position: absolute;
    top: 100%;
    left: 0;
    background: var(--background-white);
    min-width: 200px;
    box-shadow: var(--shadow-hover);
    border-radius: 16px;
    opacity: 0;
    visibility: hidden;
    transform: translateY(-10px);
    transition: var(--transition);
    margin-top: 0.5rem;
    padding: 0.5rem 0;
}

.dropdown:hover .dropdown-content {
    opacity: 1;
    visibility: visible;
    transform: translateY(0);
}

.dropdown-content a {
    display: block;
    padding: 0.75rem 1.5rem;
    color: var(--text-dark);
    text-decoration: none;
    transition: var(--transition);
    border-left: 3px solid transparent;
}

.dropdown-content a:hover {
    background: var(--background-light);
    color: var(--primary-color);
    border-left-color: var(--primary-color);
    padding-left: 1.75rem;
}


/* Sélecteur de langue - Design moderne et distinctif */
.language-switcher {
    display: flex;
    gap: 0.4rem;
    border: 2px solid rgba(44, 95, 141, 0.25);
    border-radius: 24px;
    padding: 0.4rem;
    background: rgba(255, 255, 255, 0.95);
    backdrop-filter: blur(12px);
    -webkit-backdrop-filter: blur(12px);
    box-shadow: 0 3px 15px rgba(0, 0, 0, 0.08), inset 0 1px 0 rgba(255, 255, 255, 0.9);
    flex-shrink: 0;
    transition: all 0.3s cubic-bezier(0.4, 0, 0.2, 1);
    margin-left: auto;
}

.language-switcher:hover {
    border-color: rgba(44, 95, 141, 0.5);
    box-shadow: 0 5px 20px rgba(44, 95, 141, 0.2), inset 0 1px 0 rgba(255, 255, 255, 0.9);
    transform: translateY(-1px);
}

.lang-btn {
    padding: 0.8rem 1.8rem;
    border: none;
    background: transparent;
    color: #6b7280;
    cursor: pointer;
    font-size: 1rem;
    border-radius: 24px;
    transition: all 0.3s cubic-bezier(0.4, 0, 0.2, 1);
    font-weight: 700;
    font-size: 0.95rem;
    letter-spacing: 1.2px;
    position: relative;
    overflow: hidden;
    min-width: 52px;
    text-align: center;
    text-transform: uppercase;
    font-family: 'Segoe UI', Tahoma, Geneva, Verdana, sans-serif;
    z-index: 1;
}

.lang-btn::before {
    content: '';
    position: absolute;
    top: 0;
    left: 0;
    right: 0;
    bottom: 0;
    background: linear-gradient(135deg, #2c5f8d 0%, #1e4263 100%);
    opacity: 0;
    transition: all 0.3s cubic-bezier(0.4, 0, 0.2, 1);
    border-radius: 24px;
    transform: scale(0.85);
    z-index: -1;
}

.lang-btn::after {
    content: '';
    position: absolute;
    top: 50%;
    left: 50%;
    transform: translate(-50%, -50%);
    width: 0;
    height: 0;
    background: rgba(255, 255, 255, 0.2);
    border-radius: 50%;
    transition: all 0.4s cubic-bezier(0.4, 0, 0.2, 1);
    z-index: -1;
}

.lang-btn:hover::after {
    width: 100px;
    height: 100px;
}

.lang-btn:hover {
    color: var(--primary-color);
    transform: scale(1.1);
    font-weight: 700;
    background: rgba(44, 95, 141, 0.05);
}

.lang-btn:hover::before {
    opacity: 0.15;
    transform: scale(1);
}

.lang-btn.active {
    color: #ffffff;
    box-shadow: 0 4px 18px rgba(44, 95, 141, 0.45), 
                0 2px 8px rgba(44, 95, 141, 0.3),
                inset 0 1px 0 rgba(255, 255, 255, 0.2),
                inset 0 -1px 0 rgba(0, 0, 0, 0.1);
    font-weight: 700;
    transform: scale(1.08);
    background: transparent;
}

.lang-btn.active::before {
    opacity: 1;
    transform: scale(1);
    box-shadow: inset 0 2px 4px rgba(0, 0, 0, 0.2);
    background: linear-gradient(135deg, #2c5f8d 0%, #1e4263 100%);
}

.lang-btn.active::after {
    width: 0;
    height: 0;
}

.lang-btn span {
    position: relative;
    z-index: 2;
    display: inline-block;
}

/* Amélioration de la visibilité du texte - Bouton inactif */
.lang-btn:not(.active) {
    color: #6b7280;
    font-weight: 600;
    background: rgba(107, 114, 128, 0.05);
}

.lang-btn:not(.active):hover {
    color: var(--primary-color);
    background: rgba(44, 95, 141, 0.08);
}

/* Amélioration de la visibilité du texte - Bouton actif */
.lang-btn.active {
    text-shadow: 0 1px 3px rgba(0, 0, 0, 0.3),
                 0 0 8px rgba(255, 255, 255, 0.1);
    letter-spacing: 1.5px;
}

/* Styles spécifiques pour le bouton de langue en bleu (pages principales et sepsis) */
.page-home .language-switcher,
.page-sepsis .language-switcher {
    border-color: rgba(44, 95, 141, 0.3);
    background: rgba(255, 255, 255, 0.95);
    box-shadow: 0 3px 15px rgba(0, 0, 0, 0.08), inset 0 1px 0 rgba(255, 255, 255, 0.9);
}

.page-home .language-switcher:hover,
.page-sepsis .language-switcher:hover {
    border-color: rgba(44, 95, 141, 0.5);
    box-shadow: 0 5px 20px rgba(44, 95, 141, 0.25), inset 0 1px 0 rgba(255, 255, 255, 0.9);
}

.page-home .lang-btn:not(.active),
.page-sepsis .lang-btn:not(.active) {
    color: #6b7280;
    background: rgba(107, 114, 128, 0.05);
}

.page-home .lang-btn:hover,
.page-sepsis .lang-btn:hover {
    color: #2c5f8d;
    background: rgba(44, 95, 141, 0.08);
}

.page-home .lang-btn.active::before,
.page-sepsis .lang-btn.active::before {
    background: linear-gradient(135deg, #2c5f8d 0%, #1e4263 100%);
    box-shadow: inset 0 2px 4px rgba(0, 0, 0, 0.2);
}

.page-home .lang-btn.active,
.page-sepsis .lang-btn.active {
    color: white;
    box-shadow: 0 4px 18px rgba(44, 95, 141, 0.45), 
                0 2px 8px rgba(44, 95, 141, 0.3),
                inset 0 1px 0 rgba(255, 255, 255, 0.2),
                inset 0 -1px 0 rgba(0, 0, 0, 0.1);
    text-shadow: 0 1px 3px rgba(0, 0, 0, 0.3),
                 0 0 8px rgba(255, 255, 255, 0.1);
    letter-spacing: 1.5px;
}

/* Styles harmonisés pour le bouton de langue - Bleu cohérent */
.page-drepanocytose .language-switcher {
    border-color: rgba(44, 95, 141, 0.3);
    background: rgba(255, 255, 255, 0.95);
    box-shadow: 0 3px 15px rgba(0, 0, 0, 0.08), inset 0 1px 0 rgba(255, 255, 255, 0.9);
}

.page-drepanocytose .language-switcher:hover {
    border-color: rgba(44, 95, 141, 0.5);
    box-shadow: 0 5px 20px rgba(44, 95, 141, 0.25), inset 0 1px 0 rgba(255, 255, 255, 0.9);
}

.page-drepanocytose .lang-btn:not(.active) {
    color: #6b7280;
    background: rgba(107, 114, 128, 0.05);
}

.page-drepanocytose .lang-btn:hover {
    color: var(--primary-color);
    background: rgba(44, 95, 141, 0.08);
}

.page-drepanocytose .lang-btn.active::before {
    background: linear-gradient(135deg, #2c5f8d 0%, #1e4263 100%);
    box-shadow: inset 0 2px 4px rgba(0, 0, 0, 0.2);
}

.page-drepanocytose .lang-btn.active {
    color: white;
    box-shadow: 0 4px 18px rgba(44, 95, 141, 0.45), 
                0 2px 8px rgba(44, 95, 141, 0.3),
                inset 0 1px 0 rgba(255, 255, 255, 0.2),
                inset 0 -1px 0 rgba(0, 0, 0, 0.1);
    text-shadow: 0 1px 3px rgba(0, 0, 0, 0.3),
                 0 0 8px rgba(255, 255, 255, 0.1);
    letter-spacing: 1.5px;
}

/* Contenu principal */
.main-content {
    padding-top: 80px;
}

@media (max-width: 768px) {
    .main-content {
        /* Padding-top ajusté pour la navbar verticale sur mobile */
        padding-top: 250px;
        transition: padding-top 0.3s ease;
    }
    
    /* Quand navbar est masquée */
    body.navbar-collapsed .main-content {
        padding-top: 35px !important;
    }
}

@media (max-width: 480px) {
    .main-content {
        padding-top: 280px;
        transition: padding-top 0.3s ease;
    }
    
    body.navbar-collapsed .main-content {
        padding-top: 35px !important;
    }
}

.section {
    min-height: 100vh;
    padding: 4rem 2rem;
    display: flex;
    align-items: center;
    justify-content: center;
    position: relative;
    overflow: hidden;
    width: 100%;
    box-sizing: border-box;
}

.section:nth-child(even) {
    background: var(--background-white);
}

.container {
    max-width: 1200px;
    width: 100%;
    margin: 0 auto;
    padding: 0 2rem;
    text-align: center;
    box-sizing: border-box;
}

/* Conteneurs pour différentes largeurs */
.container-wide {
    max-width: 1400px;
    width: 100%;
    margin: 0 auto;
    padding: 0 2rem;
    box-sizing: border-box;
}

.container-narrow {
    max-width: 900px;
    width: 100%;
    margin: 0 auto;
    padding: 0 2rem;
    box-sizing: border-box;
}

/* Section Hero */
.hero-section {
    background: linear-gradient(135deg, var(--primary-color) 0%, var(--primary-dark) 100%);
    color: white;
    position: relative;
    overflow: hidden;
}

.hero-section::before {
    content: '';
    position: absolute;
    top: 0;
    left: 0;
    right: 0;
    bottom: 0;
    background: url('data:image/svg+xml,<svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100"><circle cx="50" cy="50" r="2" fill="rgba(255,255,255,0.1)"/></svg>') repeat;
    opacity: 0.3;
    /* Animation supprimée */
}

/* Désactiver les cercles pour la page d'accueil */
.page-home .hero-section::before {
    display: none;
}

/* Animation @keyframes float supprimée */

.hero-content {
    position: relative;
    z-index: 1;
    text-align: center;
}

.hero-content h1 {
    font-size: 2.8rem;
    margin-bottom: 1rem;
    text-shadow: 2px 2px 4px rgba(0, 0, 0, 0.2);
    max-width: 1000px;
    margin-left: auto;
    margin-right: auto;
    line-height: 1.3;
}

.hero-content p {
    font-size: 1.5rem;
    margin-bottom: 2rem;
    opacity: 0.95;
}

/* Animation des cellules sanguines */
.hero-animation {
    position: absolute;
    width: 100%;
    height: 100%;
    top: 0;
    left: 0;
    overflow: hidden;
    z-index: 0;
}

.blood-cell {
    position: absolute;
    width: 60px;
    height: 60px;
    background: radial-gradient(circle, rgba(255,255,255,0.3) 0%, rgba(255,255,255,0.1) 100%);
    border-radius: 50%;
    opacity: 0.6;
}

.blood-cell:nth-child(1) {
    left: 10%;
    animation-delay: 0s;
    width: 80px;
    height: 80px;
}

.blood-cell:nth-child(2) {
    left: 50%;
    animation-delay: 5s;
    width: 50px;
    height: 50px;
}

.blood-cell:nth-child(3) {
    left: 80%;
    animation-delay: 10s;
    width: 70px;
    height: 70px;
}

/* Animations @keyframes floatCell, fadeInUp supprimées */

.section h2 {
    font-size: 2.5rem;
    color: var(--primary-color);
    margin-bottom: 1.5rem;
}

.section p {
    font-size: 1.2rem;
    color: var(--text-light);
    max-width: 800px;
    margin: 0 auto;
}

/* ============================================
   RESPONSIVE DESIGN - Breakpoints cohérents
   ============================================ */

/* Large tablets and small desktops (992px - 1200px) */
@media (max-width: 1200px) {
    .container {
        max-width: 100%;
        padding: 0 2rem;
    }
    
    .container-wide {
        max-width: 100%;
        padding: 0 2rem;
    }
    
    .container-narrow {
        max-width: 100%;
        padding: 0 2rem;
    }
    
    /* Assurer que les images et vidéos sont responsives */
    img, video {
        max-width: 100%;
        height: auto;
    }
    
    /* Grilles adaptatives */
    .content-grid,
    .innovations-grid,
    .process-steps {
        gap: 2rem;
    }
}

/* Tablets (768px - 992px) */
@media (max-width: 992px) {
    .nav-container {
        padding: 1rem 2rem;
        gap: 1.5rem;
    }

    .nav-menu {
        gap: 0.3rem;
    }

    .nav-link {
        padding: 0.6rem 1rem;
        font-size: 0.9rem;
    }

    .logo {
        font-size: 1.1rem;
    }
    
    .logo-image {
        height: 22px;
        max-width: none;
    }
    
    .section {
        padding: 3.5rem 2rem;
    }
    
    .container,
    .container-wide,
    .container-narrow {
        padding: 0 2rem;
    }
    
    .content-grid {
        grid-template-columns: 1fr;
        gap: 2rem;
    }
    
    .innovations-grid {
        grid-template-columns: 1fr;
    }
    
    .process-steps {
        grid-template-columns: 1fr;
        gap: 2rem;
    }
    
    .stats-grid {
        grid-template-columns: repeat(2, 1fr);
        gap: 1.5rem;
    }
    
    .section-title {
        font-size: 2.2rem;
    }
    
    /* Assurer la lisibilité des textes */
    p, li {
        font-size: 1.05rem;
        line-height: 1.7;
    }
    
    h2 {
        font-size: 2rem;
    }
    
    h3 {
        font-size: 1.6rem;
    }
    
    /* Images et vidéos */
    img, video {
        max-width: 100%;
        height: auto;
        border-radius: 16px;
    }
    
    /* Boutons */
    .btn, .cta-btn, .btn-projets {
        padding: 0.9rem 2rem;
        font-size: 1rem;
    }
}

/* Mobile landscape and small tablets (480px - 768px) */
@media (max-width: 768px) {
    .nav-container {
        flex-wrap: nowrap;
        padding: 1rem 1.5rem;
        gap: 1rem;
    }

    .logo {
        font-size: 1.6rem;
    }
    
    /* Menu toujours visible sur mobile */
    .nav-container > .nav-menu {
        display: flex !important;
    }

    .language-switcher {
        order: 3;
    }

    .hero-content h1 {
        font-size: 2rem;
        line-height: 1.3;
    }

    .hero-content p {
        font-size: 1.2rem;
        line-height: 1.6;
    }
    
    .section {
        padding: 3rem 1.5rem;
        min-height: auto;
    }
    
    .container,
    .container-wide,
    .container-narrow {
        padding: 0 1.5rem;
    }
    
    .section-title {
        font-size: 2rem;
        line-height: 1.3;
        margin-bottom: 1.5rem;
    }
    
    h2 {
        font-size: 1.8rem;
        line-height: 1.3;
    }
    
    h3 {
        font-size: 1.5rem;
        line-height: 1.3;
    }
    
    p, li {
        font-size: 1rem;
        line-height: 1.7;
    }
    
    .stats-grid {
        grid-template-columns: 1fr;
        gap: 1.5rem;
    }
    
    .publication-item {
        flex-direction: column;
        text-align: left;
        padding: 1.5rem;
        word-break: break-word;
        overflow-wrap: break-word;
    }
    
    /* Grilles en colonne unique */
    .content-grid,
    .innovations-grid,
    .process-steps {
        grid-template-columns: 1fr;
        gap: 2rem;
    }
    
    /* Images et vidéos */
    img, video {
        max-width: 100%;
        height: auto;
        border-radius: 16px;
    }
    
    /* Boutons */
    .btn, .cta-btn, .btn-projets {
        padding: 0.85rem 1.8rem;
        font-size: 0.95rem;
        width: auto;
        max-width: 100%;
    }
    
    .dropdown-content {
        left: 50%;
        transform: translateX(-50%) translateY(-10px);
    }

    .dropdown:hover .dropdown-content {
        transform: translateX(-50%) translateY(0);
    }
    
    /* Tables responsive */
    table {
        font-size: 0.9rem;
        display: block;
        overflow-x: auto;
        -webkit-overflow-scrolling: touch;
    }
    
    /* Footer */
    .footer-container {
        grid-template-columns: 1fr;
        gap: 2rem;
        text-align: center;
    }
    
    .footer-section {
        text-align: center;
    }
}

/* Mobile portrait (max-width: 480px) */
@media (max-width: 480px) {
    .nav-container {
        padding: 0.8rem;
    }

    .nav-menu {
        gap: 0.5rem !important;
        display: flex !important;
        flex-direction: column !important;
    }

    .nav-link {
        padding: 0.9rem !important;
        font-size: 0.95rem !important;
        display: block !important;
        width: 100% !important;
    }

    .logo {
        font-size: 1rem;
        letter-spacing: 0.5px;
    }
    
    .logo-image {
        height: 40px !important;
        max-height: 40px !important;
        max-width: 160px !important;
    }

    .language-switcher {
        padding: 0.25rem;
        gap: 0.25rem;
        border-width: 1.5px;
    }

    .lang-btn {
        padding: 0.5rem 1rem;
        font-size: 0.8rem;
        min-width: 42px;
        letter-spacing: 0.5px;
    }
    
    .section {
        padding: 2rem 1rem;
        min-height: auto;
    }
    
    .container,
    .container-wide,
    .container-narrow {
        padding: 0 1rem;
    }
    
    .hero-content h1 {
        font-size: 1.75rem;
    }
    
    .hero-content p {
        font-size: 1.1rem;
    }
    
    .section-title {
        font-size: 1.75rem;
    }
    
    /* Améliorations spécifiques smartphones */
    .stats-grid {
        gap: 1rem;
    }
    
    .publication-item {
        padding: 1rem;
        word-break: break-word;
        overflow-wrap: break-word;
    }
    
    .btn,
    .cta-btn,
    .btn-projets {
        padding: 0.8rem 1.5rem;
        font-size: 0.9rem;
        width: 100%;
        max-width: 100%;
        margin: 0.5rem auto;
        display: block;
        min-height: 44px; /* Taille minimale pour le touch */
        touch-action: manipulation;
        -webkit-tap-highlight-color: rgba(0, 0, 0, 0.1);
    }
    
    /* Assurer la lisibilité de tous les textes */
    p, li, span, div {
        word-break: break-word;
        overflow-wrap: break-word;
        hyphens: auto;
    }
    
    /* Assurer que les images sont bien contenues */
    img {
        max-width: 100%;
        height: auto;
        display: block;
        margin: 0 auto;
    }
    
    video {
        max-width: 100%;
        height: auto;
        display: block;
        margin: 0 auto;
    }
    
    /* Formulaires responsives */
    input, textarea, select {
        width: 100%;
        max-width: 100%;
        font-size: 1rem;
        padding: 0.75rem;
        box-sizing: border-box;
        min-height: 44px; /* Taille minimale pour le touch */
    }
    
    /* Liens accessibles */
    a {
        min-height: 44px;
        display: inline-flex;
        align-items: center;
        touch-action: manipulation;
    }
    
    /* Cards et boxes */
    .card, .box, .stat-card {
        word-break: break-word;
        overflow-wrap: break-word;
    }
    
    img,
    video {
        max-width: 100%;
        height: auto;
        border-radius: 16px;
    }
    
    .content-grid,
    .innovations-grid,
    .process-steps {
        gap: 1.5rem;
    }
    
    table {
        font-size: 0.85rem;
        display: block;
        overflow-x: auto;
        -webkit-overflow-scrolling: touch;
        width: 100%;
    }
    
    th, td {
        padding: 0.5rem;
        font-size: 0.85rem;
    }
    
    /* Footer responsive */
    .footer {
        padding: 3rem 0 1.5rem;
        margin-top: 4rem;
    }
    
    .footer-container {
        grid-template-columns: 1fr;
        gap: 2rem;
        padding: 0 1rem;
    }
    
    .footer-section {
        text-align: center;
    }
    
    .footer-links {
        justify-content: center;
        flex-wrap: wrap;
        gap: 1rem;
    }
    
    .footer-social {
        justify-content: center;
        flex-wrap: wrap;
        gap: 1rem;
    }
    
    .footer-link,
    .footer-social a {
        min-height: 44px;
        display: inline-flex;
        align-items: center;
        touch-action: manipulation;
    }
}

/* Smooth scroll */
html {
    scroll-behavior: smooth;
}

/* Styles pour les sections actives */
.section {
    opacity: 1;
}

/* Sections de contenu */
.content-section {
    min-height: auto;
    padding: 5rem 2rem;
    width: 100%;
    box-sizing: border-box;
    overflow-x: hidden;
}

.content-section.alt-section {
    background: var(--background-white);
}

.content-grid {
    display: grid;
    grid-template-columns: 1fr 1fr;
    gap: 4rem;
    align-items: center;
    max-width: 1200px;
    margin: 0 auto;
    width: 100%;
    box-sizing: border-box;
}

/* Images et médias - Contenus dans leurs cadres */
img {
    max-width: 100%;
    height: auto;
    display: block;
    box-sizing: border-box;
}

img[class*="image"],
img[class*="img"] {
    width: 100%;
    max-width: 100%;
    height: auto;
    object-fit: contain;
    object-position: center;
}

video {
    max-width: 100%;
    height: auto;
    display: block;
    box-sizing: border-box;
}

video[class*="video"],
video[class*="process-video"] {
    width: 100%;
    max-width: 100%;
    height: auto;
    object-fit: contain;
    object-position: center;
}

/* Conteneurs pour images et vidéos */
.image-container,
.video-container,
.media-container {
    width: 100%;
    max-width: 100%;
    overflow: hidden;
    position: relative;
    box-sizing: border-box;
}

.image-container img,
.video-container video {
    width: 100%;
    height: auto;
    display: block;
}

.content-grid.reverse {
    direction: rtl;
}

.content-grid.reverse > * {
    direction: ltr;
}

.content-text {
    text-align: left;
}

.content-text h2 {
    font-size: 2.2rem;
    color: var(--primary-color);
    margin-bottom: 1.5rem;
    line-height: 1.3;
}

.content-text p {
    font-size: 1.1rem;
    color: var(--text-dark);
    margin-bottom: 1.5rem;
    line-height: 1.8;
    text-align: left;
}

/* Boîte de déformation */
.deformation-box {
    background: linear-gradient(135deg, var(--background-light) 0%, var(--background-white) 100%);
    border: 2px solid var(--border-color);
    border-radius: 20px;
    padding: 2rem;
    min-height: 300px;
    display: flex;
    align-items: center;
    justify-content: center;
    position: relative;
    overflow: hidden;
    box-shadow: var(--shadow);
    transition: var(--transition);
}

/* Animation hover supprimée pour les éléments non-cliquables */

.deformation-box::before {
    content: '';
    position: absolute;
    width: 200px;
    height: 200px;
    background: radial-gradient(circle, var(--primary-light) 0%, transparent 70%);
    opacity: 0.1;
    border-radius: 50%;
    /* Animation supprimée */
}

/* Animation @keyframes pulse supprimée */

.deformation-label {
    position: relative;
    z-index: 1;
    font-size: 1rem;
    color: var(--text-dark);
    font-weight: 500;
    text-align: center;
    padding: 1rem;
    background: rgba(255, 255, 255, 0.9);
    border-radius: 10px;
    box-shadow: 0 2px 10px rgba(0, 0, 0, 0.1);
}

/* Diagramme fTT */
.ftt-diagram {
    background: var(--background-white);
    border-radius: 20px;
    padding: 2rem;
    box-shadow: var(--shadow);
    transition: var(--transition);
}

/* Animation hover supprimée pour les éléments non-cliquables */

.ftt-visualization {
    display: flex;
    flex-direction: column;
    gap: 2rem;
}

.blood-sample {
    text-align: center;
    padding: 1rem;
    background: var(--background-light);
    border-radius: 10px;
    border: 2px dashed var(--primary-color);
}

.sample-label {
    font-weight: bold;
    color: var(--primary-color);
    font-size: 1.1rem;
}

.cells-container {
    display: flex;
    justify-content: space-around;
    align-items: flex-start;
    gap: 2rem;
    padding: 1.5rem;
    background: linear-gradient(to bottom, rgba(196, 30, 58, 0.05) 0%, transparent 100%);
    border-radius: 10px;
}

.cell-group {
    display: flex;
    flex-direction: column;
    align-items: center;
    gap: 1rem;
}

.cell {
    width: 50px;
    height: 50px;
    border-radius: 50%;
    /* Animation supprimée */
}

.cell.deformable {
    background: radial-gradient(circle, var(--primary-color) 0%, var(--primary-dark) 100%);
    box-shadow: 0 2px 10px rgba(196, 30, 58, 0.3);
}

.cell.non-deformable {
    background: radial-gradient(circle, #ff8c42 0%, #ff6b35 100%);
    box-shadow: 0 2px 10px rgba(255, 140, 66, 0.3);
    transform: scale(0.9);
}

/* Animation @keyframes cellPulse supprimée */

.cell-label {
    font-size: 0.9rem;
    color: var(--text-dark);
    font-weight: 500;
    text-align: center;
    max-width: 150px;
}

.ftt-formula {
    text-align: center;
    padding: 1.5rem;
    background: linear-gradient(135deg, var(--primary-color) 0%, var(--primary-dark) 100%);
    border-radius: 10px;
    color: white;
}

.formula-text {
    font-size: 1.3rem;
    font-weight: bold;
    display: block;
}

.ftt-ranges {
    display: flex;
    gap: 1rem;
    justify-content: center;
    flex-wrap: wrap;
}

.range-box {
    flex: 1;
    min-width: 200px;
    padding: 1.5rem;
    border-radius: 10px;
    text-align: center;
    box-shadow: var(--shadow);
    transition: var(--transition);
}

.range-box:hover {
    transform: translateY(-5px);
    box-shadow: var(--shadow-hover);
}

.range-box.normal {
    background: linear-gradient(135deg, var(--primary-color) 0%, var(--primary-dark) 100%);
    color: white;
}

.range-box.abnormal {
    background: linear-gradient(135deg, #ff8c42 0%, #ff6b35 100%);
    color: white;
}

.range-label {
    font-size: 1rem;
    font-weight: bold;
    margin-bottom: 0.5rem;
}

.range-value {
    font-size: 1.5rem;
    font-weight: bold;
}

.range-note {
    width: 100%;
    text-align: center;
    margin-top: 1rem;
    font-size: 0.9rem;
    color: var(--text-light);
    font-style: italic;
}

/* Section Parcours d'impact */
.section-title {
    font-size: 2.5rem;
    color: var(--primary-color);
    margin-bottom: 3rem;
    text-align: center;
}

.impact-steps {
    display: flex;
    align-items: center;
    justify-content: center;
    flex-wrap: wrap;
    gap: 2rem;
    max-width: 1400px;
    margin: 0 auto;
    width: 100%;
    box-sizing: border-box;
    padding: 0 1rem;
}

.step-card {
    flex: 1;
    min-width: 250px;
    max-width: 280px;
    background: var(--background-white);
    border: 2px solid var(--border-color);
    border-radius: 20px;
    padding: 2rem;
    text-align: center;
    box-shadow: var(--shadow);
    transition: var(--transition);
    position: relative;
    overflow: hidden;
    width: 100%;
    box-sizing: border-box;
}

.step-card::before {
    content: '';
    position: absolute;
    top: 0;
    left: 0;
    right: 0;
    height: 5px;
    background: linear-gradient(90deg, var(--primary-color) 0%, var(--accent-color) 100%);
    transform: scaleX(0);
    transition: var(--transition);
}

/* Effets hover supprimés pour les cartes non-cliquables */

.step-icon {
    display: flex;
    justify-content: center;
    align-items: center;
    gap: 0.5rem;
    margin-bottom: 1rem;
    min-height: 80px;
    position: relative;
}

.icon-magnifier,
.icon-heart,
.icon-brain,
.icon-phone,
.icon-patient,
.icon-piggy,
.icon-shield,
.icon-chart-down {
    width: 40px;
    height: 40px;
    background: var(--primary-color);
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    color: white;
    font-size: 1.2rem;
    box-shadow: 0 2px 8px rgba(196, 30, 58, 0.3);
}

/* ============================================
   ICÔNES - Tous les styles ::before pour les icônes
   ============================================ */
.icon-magnifier::before { content: '🔍'; }
.icon-heart::before { content: '❤️'; }
.icon-brain::before { content: '🧠'; }
.icon-phone::before { content: '📱'; }
.icon-patient::before { content: '👤'; }
.icon-piggy::before { content: '🐷'; }
.icon-shield::before { content: '🛡️'; }
.icon-chart-down::before { content: '📉'; }
.icon-microscope::before { content: '🔬'; }
.icon-ai::before { content: '🤖'; }
.icon-biomarker::before { content: '🧪'; }
.icon-marker::before { content: '📍'; }
.icon-measure::before { content: '📏'; }
.icon-device::before { content: '💻'; }
.icon-app::before { content: '📱'; }
.icon-rbc-healthy::before { content: '🩸'; }
.icon-pathogen::before { content: '🦠'; }
.icon-microscope-blue::before { content: '🔬'; }
.icon-viscosity::before { content: '🌊'; }
.icon-individual::before { content: '🔴'; }
.icon-drop::before { content: '💧'; }
.icon-monitor::before { content: '🖥️'; }
.icon-shear::before { content: '⚡'; }
.icon-infection::before { content: '🦠'; }
.icon-organ::before { content: '👤'; }
.icon-lightning::before { content: '⚡'; }
.icon-clock::before { content: '⏰'; }
.icon-people::before { content: '👥'; }
.icon-money::before { content: '💰'; }
.icon-growth::before { content: '📈'; }
.icon-healthcare::before { content: '🏥'; }
.icon-rbc-center::before { content: '🩸'; }
.icon-early::before { content: '⏰'; }
.icon-correlation::before { content: '📊'; }
.icon-mortality::before { content: '❤️'; }
.icon-monitoring::before { content: '🔬'; }
.icon-growth-center::before { content: '📈'; }
.icon-innovation::before { content: '🧠'; }
.icon-efficacy::before { content: '➕'; }
.icon-benefit::before { content: '❤️'; }
.icon-costs::before { content: '💰'; }
.icon-people-world::before { content: '👥'; }
.icon-baby::before { content: '👶'; }
.icon-dna::before { content: '🧬'; }
.icon-sickle-cell::before { content: '🩸'; }
.icon-lungs::before { content: '🫁'; }
.icon-lifespan::before { content: '⏰'; }
.icon-brain-stroke::before { content: '🧠'; }
.icon-frustration::before { content: '😤'; }
.icon-worry::before { content: '😟'; }
.icon-family::before { content: '👨‍👩‍👧'; }
.icon-cost-2024::before { content: '💰'; }
.icon-cost-2030::before { content: '💳'; }
.icon-email::before { content: '✉️'; }
.icon-phone::before { content: '📞'; }
.icon-location::before { content: '📍'; }
.icon-project-drepanocytose::before { content: '🩸'; }
.icon-project-sepsis::before { content: '🔬'; }

.step-number {
    position: absolute;
    top: -10px;
    right: -10px;
    width: 40px;
    height: 40px;
    background: var(--primary-color);
    color: white;
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    font-weight: bold;
    font-size: 1.2rem;
    box-shadow: 0 2px 8px rgba(196, 30, 58, 0.4);
}

.step-card h3 {
    font-size: 1.1rem;
    color: var(--text-dark);
    line-height: 1.5;
    margin-top: 1rem;
}

.step-arrow {
    font-size: 2rem;
    color: var(--primary-color);
    font-weight: bold;
    animation: arrowPulse 2s ease-in-out infinite;
}

@keyframes arrowPulse {
    0%, 100% { transform: translateX(0); opacity: 1; }
    50% { transform: translateX(10px); opacity: 0.7; }
}

/* Responsive pour les nouvelles sections */
@media (max-width: 968px) {
    .content-grid {
        grid-template-columns: 1fr;
        gap: 2rem;
    }

    .content-grid.reverse {
        direction: ltr;
    }

    .content-text {
        text-align: center;
    }

    .content-text p {
        text-align: center;
    }

    .hero-content h1 {
        font-size: 2rem;
    }

    .impact-steps {
        flex-direction: column;
    }

    .step-arrow {
        transform: rotate(90deg);
    }

    .ftt-ranges {
        flex-direction: column;
    }

    .range-box {
        min-width: 100%;
    }
}

/* Styles pour la section Technologies */
.tech-intro {
    text-align: center;
    margin-bottom: 4rem;
}

.tech-intro h2 {
    font-size: 2.5rem;
    color: var(--primary-color);
    margin-bottom: 1.5rem;
}

.intro-text {
    font-size: 1.3rem;
    color: var(--text-dark);
    max-width: 900px;
    margin: 0 auto;
    line-height: 1.8;
}

.tech-innovation {
    margin: 4rem 0;
    padding: 3rem 0;
    background: var(--background-white);
    border-radius: 20px;
}

.tech-innovation h3 {
    font-size: 2rem;
    color: var(--primary-color);
    margin-bottom: 1.5rem;
}

.innovation-diagram {
    background: var(--background-light);
    border: 2px dashed var(--primary-color);
    border-radius: 20px;
    padding: 3rem;
    min-height: 300px;
    display: flex;
    align-items: center;
    justify-content: center;
    box-shadow: var(--shadow);
}

.diagram-placeholder {
    text-align: center;
    color: var(--text-light);
    font-style: italic;
}

/* Processus en 3 étapes */
.tech-process {
    margin: 5rem 0;
}

.section-subtitle {
    font-size: 2rem;
    color: var(--primary-color);
    text-align: center;
    margin-bottom: 3rem;
}

.process-steps {
    display: grid;
    grid-template-columns: repeat(3, 1fr);
    gap: 2rem;
    margin-top: 3rem;
}

.process-step {
    background: var(--background-white);
    border-radius: 20px;
    padding: 2rem;
    text-align: center;
    box-shadow: var(--shadow);
    transition: var(--transition);
    position: relative;
    border: 2px solid transparent;
}

.process-step:hover {
    transform: translateY(-10px);
    box-shadow: var(--shadow-hover);
    border-color: var(--primary-color);
}

.process-number {
    position: absolute;
    top: -20px;
    left: 50%;
    transform: translateX(-50%);
    width: 50px;
    height: 50px;
    background: var(--primary-color);
    color: white;
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    font-weight: bold;
    font-size: 1.5rem;
    box-shadow: 0 4px 10px rgba(196, 30, 58, 0.4);
}

.process-icon {
    margin: 2rem 0 1rem;
    display: flex;
    justify-content: center;
}

.icon-microscope,
.icon-ai,
.icon-biomarker,
.icon-marker,
.icon-measure,
.icon-device,
.icon-app {
    width: 80px;
    height: 80px;
    background: linear-gradient(135deg, var(--primary-color) 0%, var(--primary-dark) 100%);
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    color: white;
    font-size: 2rem;
    box-shadow: 0 4px 15px rgba(196, 30, 58, 0.3);
}

.process-step h4 {
    font-size: 1.3rem;
    color: var(--primary-color);
    margin: 1rem 0;
}

.process-step p {
    color: var(--text-dark);
    margin-bottom: 1.5rem;
    line-height: 1.6;
}

.process-visual {
    background: var(--background-light);
    border-radius: 10px;
    padding: 2rem;
    min-height: 200px;
    display: flex;
    align-items: center;
    justify-content: center;
    border: 2px dashed var(--border-color);
    margin-top: 1rem;
}

.visual-placeholder {
    text-align: center;
    color: var(--text-light);
    font-style: italic;
}

/* 4 Innovations technologiques */
.tech-innovations {
    margin: 5rem 0;
    background: var(--background-light);
    padding: 4rem 2rem;
    border-radius: 20px;
}

.innovations-grid {
    display: grid;
    grid-template-columns: repeat(2, 1fr);
    gap: 2rem;
    margin-top: 3rem;
}

.innovation-card {
    background: var(--background-white);
    border-radius: 20px;
    padding: 2rem;
    box-shadow: var(--shadow);
    transition: var(--transition);
    border-left: 4px solid var(--primary-color);
}

/* Animation hover supprimée pour les éléments non-cliquables */

.innovation-icon {
    margin-bottom: 1.5rem;
    display: flex;
    justify-content: flex-start;
}

.innovation-icon .icon-marker,
.innovation-icon .icon-measure,
.innovation-icon .icon-device,
.innovation-icon .icon-app {
    width: 60px;
    height: 60px;
    font-size: 1.5rem;
    background: linear-gradient(135deg, var(--primary-color) 0%, var(--primary-dark) 100%);
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    color: white;
    box-shadow: 0 4px 15px rgba(196, 30, 58, 0.3);
}

.innovation-card h4 {
    font-size: 1.2rem;
    color: var(--primary-color);
    margin-bottom: 1rem;
    line-height: 1.4;
}

.innovation-card p,
.innovation-card li {
    color: var(--text-dark);
    line-height: 1.8;
    margin-bottom: 0.5rem;
}

.innovation-card ul {
    list-style: none;
    padding-left: 0;
}

.innovation-card li::before {
    content: "• ";
    color: var(--primary-color);
    font-weight: bold;
    margin-right: 0.5rem;
}

/* Publications scientifiques */
.tech-publications {
    margin: 5rem 0;
}

.publications-list {
    display: flex;
    flex-direction: column;
    gap: 1.5rem;
    margin-top: 2rem;
}

.publication-item {
    display: flex;
    gap: 2rem;
    background: var(--background-white);
    border-radius: 20px;
    padding: 2rem;
    box-shadow: var(--shadow);
    transition: var(--transition);
    border-left: 4px solid var(--accent-color);
}

/* Effets hover supprimés pour les éléments non-cliquables (les liens publication-link gardent leur hover) */

.publication-year {
    min-width: 80px;
    height: 80px;
    background: linear-gradient(135deg, var(--primary-color) 0%, var(--primary-dark) 100%);
    color: white;
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    font-weight: bold;
    font-size: 1.2rem;
    flex-shrink: 0;
    box-shadow: 0 4px 10px rgba(196, 30, 58, 0.3);
}

.publication-content {
    flex: 1;
}

.publication-title {
    font-weight: bold;
    color: var(--text-dark);
    margin-bottom: 0.5rem;
    line-height: 1.5;
    font-size: 1.1rem;
}

.publication-authors {
    color: var(--text-light);
    font-style: italic;
    margin-bottom: 0.5rem;
    font-size: 0.95rem;
}

.publication-journal {
    color: var(--primary-color);
    font-weight: 500;
    margin-bottom: 0.5rem;
}

.publication-link {
    display: inline-block;
    color: var(--accent-color);
    text-decoration: none;
    font-weight: 500;
    transition: var(--transition);
    margin-top: 0.5rem;
}

.publication-link:hover {
    color: var(--primary-color);
    text-decoration: underline;
}

/* Brevet */
.tech-patent {
    margin: 5rem 0;
}

.patent-box {
    background: linear-gradient(135deg, var(--primary-color) 0%, var(--primary-dark) 100%);
    border-radius: 20px;
    padding: 3rem;
    display: flex;
    align-items: center;
    gap: 2rem;
    box-shadow: var(--shadow-hover);
    color: white;
}

.patent-icon {
    font-size: 4rem;
    flex-shrink: 0;
}

.patent-content h4 {
    font-size: 1.5rem;
    margin-bottom: 1rem;
    text-transform: uppercase;
    letter-spacing: 1px;
}

.patent-title {
    font-size: 1.2rem;
    font-weight: bold;
    margin-bottom: 0.5rem;
    line-height: 1.5;
}

.patent-authors {
    font-size: 1rem;
    margin-bottom: 0.5rem;
    opacity: 0.95;
}

.patent-numbers {
    font-size: 0.95rem;
    opacity: 0.9;
    font-family: 'Courier New', monospace;
}

@media (max-width: 768px) {
    .hero-content h1 {
        font-size: 1.5rem;
    }

    .content-text h2 {
        font-size: 1.8rem;
    }

    .section-title {
        font-size: 2rem;
    }

    .step-card {
        min-width: 100%;
        max-width: 100%;
    }

    .process-steps {
        grid-template-columns: 1fr;
    }

    .innovations-grid {
        grid-template-columns: 1fr;
    }

    .publication-item {
        flex-direction: column;
        text-align: center;
    }

    .publication-year {
        align-self: center;
    }

    .patent-box {
        flex-direction: column;
        text-align: center;
    }
}

/* Styles pour la section Recherche */
.research-intro {
    text-align: center;
    margin-bottom: 4rem;
}

.research-intro h2 {
    font-size: 2.5rem;
    color: var(--primary-color);
    margin-bottom: 1.5rem;
    line-height: 1.3;
}

/* Infographie 3 panneaux */
.research-infographic {
    display: grid;
    grid-template-columns: repeat(3, 1fr);
    gap: 2rem;
    margin: 4rem 0;
}

.infographic-panel {
    background: var(--background-white);
    border-radius: 20px;
    padding: 2.5rem 2rem;
    text-align: center;
    box-shadow: var(--shadow);
    transition: var(--transition);
    border-top: 4px solid var(--primary-color);
}

/* Effets hover supprimés pour les éléments non-cliquables */

.panel-icon {
    margin-bottom: 1.5rem;
    display: flex;
    justify-content: center;
    min-height: 100px;
    align-items: center;
}

.icon-rbc-healthy,
.icon-pathogen,
.icon-microscope-blue,
.icon-viscosity,
.icon-individual,
.icon-drop,
.icon-monitor,
.icon-shear {
    width: 80px;
    height: 80px;
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    font-size: 2.5rem;
    box-shadow: 0 4px 15px rgba(0, 0, 0, 0.1);
}

.icon-rbc-healthy {
    background: linear-gradient(135deg, #ff8c42 0%, #ff6b35 100%);
}

.icon-pathogen {
    background: linear-gradient(135deg, #ff8c42 0%, #ff6b35 100%);
}

.icon-microscope-blue {
    background: linear-gradient(135deg, #3498db 0%, #2980b9 100%);
}

.infographic-panel p {
    color: var(--text-dark);
    font-size: 1.1rem;
    line-height: 1.7;
    margin: 0;
}

/* Avantages DYNARED */
.research-advantages {
    margin: 5rem 0;
    background: var(--background-light);
    padding: 4rem 2rem;
    border-radius: 20px;
}

.advantages-list {
    display: flex;
    flex-direction: column;
    gap: 2rem;
    margin-top: 3rem;
}

.advantage-item {
    display: flex;
    align-items: flex-start;
    gap: 2rem;
    background: var(--background-white);
    border-radius: 20px;
    padding: 2rem;
    box-shadow: var(--shadow);
    transition: var(--transition);
    border-left: 4px solid var(--primary-color);
}

/* Effets hover supprimés pour les éléments non-cliquables */

.advantage-icon {
    flex-shrink: 0;
}

.icon-viscosity {
    background: linear-gradient(135deg, var(--primary-color) 0%, var(--primary-dark) 100%);
}

.icon-individual {
    background: linear-gradient(135deg, var(--primary-color) 0%, var(--primary-dark) 100%);
}

.icon-drop {
    background: linear-gradient(135deg, #3498db 0%, #2980b9 100%);
}

.advantage-item p {
    color: var(--text-dark);
    font-size: 1.1rem;
    line-height: 1.8;
    margin: 0;
    flex: 1;
}

/* Caractéristiques techniques */
.research-features {
    margin: 5rem 0;
}

.features-grid {
    display: grid;
    grid-template-columns: repeat(2, 1fr);
    gap: 2rem;
    margin-top: 2rem;
}

.feature-item {
    background: var(--background-white);
    border-radius: 20px;
    padding: 2.5rem;
    display: flex;
    align-items: center;
    gap: 2rem;
    box-shadow: var(--shadow);
    transition: var(--transition);
}

/* Effets hover supprimés pour les éléments non-cliquables */

.feature-icon {
    flex-shrink: 0;
}

.icon-monitor {
    background: linear-gradient(135deg, #3498db 0%, #2980b9 100%);
}

.icon-shear {
    background: linear-gradient(135deg, #ff8c42 0%, #ff6b35 100%);
}

.feature-item p {
    color: var(--text-dark);
    font-size: 1.1rem;
    line-height: 1.7;
    margin: 0;
    flex: 1;
}

/* Sensibilité fTT */
.research-sensitivity {
    margin: 5rem 0;
}

.sensitivity-box {
    background: linear-gradient(135deg, var(--primary-color) 0%, var(--primary-dark) 100%);
    border-radius: 20px;
    padding: 3rem;
    color: white;
    text-align: center;
    box-shadow: var(--shadow-hover);
}

.sensitivity-box h3 {
    font-size: 1.8rem;
    margin-bottom: 2rem;
    line-height: 1.4;
}

.publication-ref {
    background: rgba(255, 255, 255, 0.1);
    border-radius: 10px;
    padding: 1.5rem;
    margin-top: 1.5rem;
}

.ref-journal {
    font-size: 1.1rem;
    font-weight: 500;
    margin-bottom: 0.5rem;
}

.ref-link {
    color: white;
    text-decoration: underline;
    font-size: 0.95rem;
    transition: var(--transition);
    display: inline-block;
}

.ref-link:hover {
    opacity: 0.8;
    transform: translateY(-2px);
}

/* Figure scientifique */
.research-figure {
    margin: 5rem 0;
}

.figure-container {
    background: var(--background-white);
    border-radius: 20px;
    padding: 2rem;
    box-shadow: var(--shadow);
}

.figure-placeholder {
    background: var(--background-light);
    border: 2px dashed var(--border-color);
    border-radius: 10px;
    padding: 4rem 2rem;
    min-height: 400px;
    display: flex;
    align-items: center;
    justify-content: center;
    margin-bottom: 2rem;
}

.figure-label {
    text-align: center;
    color: var(--text-light);
    font-style: italic;
    font-size: 1.1rem;
}

.figure-caption {
    padding: 0 1rem;
}

.caption-title {
    font-size: 1.3rem;
    font-weight: bold;
    color: var(--primary-color);
    margin-bottom: 1.5rem;
    text-align: center;
}

.caption-content p {
    color: var(--text-dark);
    font-size: 1rem;
    line-height: 1.8;
    margin-bottom: 1rem;
    text-align: left;
}

.caption-content strong {
    color: var(--primary-color);
    font-weight: bold;
}

/* Responsive pour la section Recherche */
@media (max-width: 968px) {
    .research-infographic {
        grid-template-columns: 1fr;
    }

    .features-grid {
        grid-template-columns: 1fr;
    }

    .advantage-item {
        flex-direction: column;
        text-align: center;
    }

    .feature-item {
        flex-direction: column;
        text-align: center;
    }
}

@media (max-width: 768px) {
    .research-intro h2 {
        font-size: 2rem;
    }

    .sensitivity-box h3 {
        font-size: 1.5rem;
    }
}

/* Styles pour la section Sepsis */
.sepsis-intro {
    text-align: center;
    margin-bottom: 4rem;
}

.sepsis-intro h2 {
    font-size: 2.5rem;
    color: var(--primary-color);
    margin-bottom: 1rem;
}

.intro-subtitle {
    font-size: 1.3rem;
    color: var(--text-dark);
    max-width: 900px;
    margin: 0 auto;
    line-height: 1.6;
}

/* Infographie Sepsis */
.sepsis-infographic {
    margin: 4rem 0;
    padding: 3rem;
    background: var(--background-light);
    border-radius: 20px;
}

.infographic-flow {
    display: flex;
    flex-direction: column;
    align-items: center;
    gap: 1.5rem;
}

.flow-item {
    background: var(--background-white);
    border-radius: 20px;
    padding: 2rem;
    text-align: center;
    box-shadow: var(--shadow);
    min-width: 300px;
    max-width: 500px;
}

.flow-item.infection {
    border-top: 4px solid var(--accent-color);
}

.flow-item.organ {
    border-top: 4px solid #ff8c42;
}

.flow-item.shock {
    border-top: 4px solid var(--primary-color);
    display: flex;
    align-items: center;
    gap: 1rem;
}

.flow-item.time {
    border-top: 4px solid var(--accent-color);
    display: flex;
    align-items: center;
    gap: 1rem;
}

.flow-icon {
    margin-bottom: 1rem;
    display: flex;
    justify-content: center;
}

.icon-infection,
.icon-organ,
.icon-lightning,
.icon-clock {
    width: 60px;
    height: 60px;
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    font-size: 1.8rem;
    box-shadow: 0 4px 15px rgba(0, 0, 0, 0.1);
}

.icon-infection {
    background: linear-gradient(135deg, var(--accent-color) 0%, #2980b9 100%);
}

.icon-organ {
    background: linear-gradient(135deg, #ff8c42 0%, #ff6b35 100%);
}

.icon-lightning {
    background: linear-gradient(135deg, #ff8c42 0%, #ff6b35 100%);
    width: 50px;
    height: 50px;
}

.icon-clock {
    background: linear-gradient(135deg, var(--accent-color) 0%, #2980b9 100%);
    width: 50px;
    height: 50px;
}

.flow-item p {
    color: var(--text-dark);
    font-size: 1rem;
    line-height: 1.6;
    margin: 0;
}

.flow-arrow {
    font-size: 2rem;
    color: var(--accent-color);
    font-weight: bold;
}

.flow-branches {
    display: flex;
    gap: 3rem;
    margin-top: 1rem;
}

.flow-branch {
    display: flex;
    flex-direction: column;
    align-items: center;
    gap: 1rem;
}

/* Statistiques */
.sepsis-stats {
    margin: 5rem 0;
}

.stats-grid {
    display: grid;
    grid-template-columns: repeat(4, 1fr);
    gap: 2rem;
    margin-top: 3rem;
}

.stat-card {
    background: var(--background-white);
    border-radius: 20px;
    padding: 2.5rem 2rem;
    text-align: center;
    box-shadow: var(--shadow);
    transition: var(--transition);
    border-top: 4px solid var(--primary-color);
}

/* Effets hover supprimés pour les cartes non-cliquables */

.stat-icon {
    margin-bottom: 1.5rem;
    display: flex;
    justify-content: center;
}

.icon-people,
.icon-money,
.icon-growth,
.icon-healthcare {
    width: 70px;
    height: 70px;
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    font-size: 2rem;
    box-shadow: 0 4px 15px rgba(196, 30, 58, 0.2);
}

.icon-people {
    background: linear-gradient(135deg, var(--accent-color) 0%, #2980b9 100%);
}

.icon-money {
    background: linear-gradient(135deg, var(--accent-color) 0%, #2980b9 100%);
}

.icon-growth {
    background: linear-gradient(135deg, var(--primary-color) 0%, var(--primary-dark) 100%);
}

.icon-healthcare {
    background: linear-gradient(135deg, var(--primary-color) 0%, var(--primary-dark) 100%);
}

.stat-value {
    font-size: 2rem;
    font-weight: bold;
    color: var(--primary-color);
    margin-bottom: 0.5rem;
}

.stat-label {
    font-size: 0.95rem;
    color: var(--text-dark);
    line-height: 1.5;
}

/* Besoin clinique */
.sepsis-need {
    margin: 5rem 0;
}

.need-box {
    background: var(--background-white);
    border-radius: 20px;
    padding: 3rem;
    box-shadow: var(--shadow);
    border-left: 4px solid var(--primary-color);
}

.need-box h3 {
    font-size: 1.8rem;
    color: var(--primary-color);
    margin-bottom: 1.5rem;
    line-height: 1.4;
}

.need-box > p {
    font-size: 1.1rem;
    color: var(--text-dark);
    line-height: 1.8;
    margin-bottom: 2rem;
}

.quote-box {
    background: var(--background-light);
    border-radius: 10px;
    padding: 2rem;
    margin-top: 2rem;
    border-left: 4px solid var(--accent-color);
    position: relative;
}

.quote-icon {
    font-size: 4rem;
    color: var(--accent-color);
    opacity: 0.3;
    position: absolute;
    top: -10px;
    left: 20px;
    font-family: Georgia, serif;
}

.quote-text {
    font-size: 1.1rem;
    color: var(--text-dark);
    line-height: 1.8;
    font-style: italic;
    margin-bottom: 1.5rem;
    position: relative;
    z-index: 1;
}

.quote-author {
    text-align: right;
    font-weight: bold;
    color: var(--primary-color);
    font-size: 1rem;
    margin: 0;
}

.quote-author span {
    font-weight: normal;
    font-size: 0.9rem;
    color: var(--text-light);
    display: block;
    margin-top: 0.5rem;
}

/* Popup pour les citations */
.quote-popup {
    display: none;
    position: fixed;
    top: 0;
    left: 0;
    width: 100%;
    height: 100%;
    background: rgba(0, 0, 0, 0.6);
    z-index: 10000;
    justify-content: center;
    align-items: center;
    padding: 1rem;
    animation: fadeIn 0.3s ease;
}

.quote-popup.active {
    display: flex;
}

.quote-popup-content {
    background: white;
    border-radius: 20px;
    padding: 2.5rem;
    max-width: 600px;
    width: 100%;
    max-height: 80vh;
    overflow-y: auto;
    position: relative;
    box-shadow: 0 10px 40px rgba(0, 0, 0, 0.3);
    animation: slideUp 0.3s ease;
}

.quote-popup-close {
    position: absolute;
    top: 1rem;
    right: 1rem;
    background: none;
    border: none;
    font-size: 2rem;
    color: #666;
    cursor: pointer;
    line-height: 1;
    padding: 0;
    width: 2rem;
    height: 2rem;
    display: flex;
    align-items: center;
    justify-content: center;
    border-radius: 50%;
    transition: all 0.3s ease;
}

.quote-popup-close:hover {
    background: #f0f0f0;
    color: #333;
    transform: rotate(90deg);
}

.quote-popup-text {
    font-size: 1.3rem;
    line-height: 1.8;
    color: #2c3e50;
    font-style: italic;
    margin-bottom: 1.5rem;
    text-align: left;
    position: relative;
    padding-left: 2rem;
}

.quote-popup-text::before {
    content: '"';
    position: absolute;
    left: 0;
    top: -10px;
    font-size: 4rem;
    color: var(--primary-color);
    opacity: 0.3;
    font-family: serif;
}

body.page-drepanocytose .quote-popup-text::before {
    color: var(--project-primary);
}

body.page-sepsis .quote-popup-text::before {
    color: var(--project-primary);
}

.quote-popup-author {
    text-align: right;
    font-size: 1.1rem;
    color: var(--primary-color);
    font-weight: 600;
    margin: 0;
}

body.page-drepanocytose .quote-popup-author {
    color: var(--project-primary);
}

body.page-sepsis .quote-popup-author {
    color: var(--project-primary);
}

@keyframes fadeIn {
    from {
        opacity: 0;
    }
    to {
        opacity: 1;
    }
}

@keyframes slideUp {
    from {
        transform: translateY(30px);
        opacity: 0;
    }
    to {
        transform: translateY(0);
        opacity: 1;
    }
}

/* Note cliquable globale */
.quote-note-container {
    margin-top: 2rem;
    text-align: center;
}

.quote-note {
    display: inline-flex;
    align-items: center;
    gap: 0.5rem;
    cursor: pointer;
    color: var(--primary-color);
    font-weight: 600;
    font-size: 1.1rem;
    padding: 0.3rem 0.6rem;
    border-radius: 4px;
    background: rgba(44, 95, 141, 0.1);
    transition: all 0.3s ease;
    text-decoration: none;
    user-select: none;
}

.quote-note:hover {
    background: rgba(44, 95, 141, 0.2);
    transform: scale(1.1);
}

.quote-note:active {
    transform: scale(0.95);
}

.quote-note-number {
    display: inline;
}

.quote-note-title {
    display: none;
}

/* Sur mobile, afficher uniquement le titre */
@media (max-width: 768px) {
    .quote-note {
        display: inline-block;
        width: auto;
        max-width: 100%;
        text-align: center;
        padding: 0.8rem 1.2rem;
        font-size: 1rem;
    }
    
    .quote-note-number {
        display: none;
    }
    
    .quote-note-title {
        display: inline;
        font-weight: 600;
    }
}

/* Responsive pour la popup de citation */
@media (max-width: 768px) {
    .quote-popup-content {
        padding: 2rem 1.5rem;
        max-width: 90%;
        max-height: 85vh;
    }
    
    .quote-popup-text {
        font-size: 1.1rem;
        padding-left: 1.5rem;
    }
    
    .quote-popup-text::before {
        font-size: 3rem;
        top: -5px;
    }
    
    .quote-popup-author {
        font-size: 1rem;
    }
    
    .quote-popup-close {
        top: 0.5rem;
        right: 0.5rem;
        font-size: 1.8rem;
    }
}

@media (max-width: 480px) {
    .quote-popup-content {
        padding: 1.5rem 1rem;
        max-width: 95%;
        max-height: 90vh;
    }
    
    .quote-popup-text {
        font-size: 1rem;
        padding-left: 1rem;
        line-height: 1.6;
    }
    
    .quote-popup-text::before {
        font-size: 2.5rem;
        top: -3px;
    }
    
    .quote-popup-author {
        font-size: 0.95rem;
    }
    
    .quote-popup-close {
        top: 0.3rem;
        right: 0.3rem;
        font-size: 1.5rem;
        width: 1.8rem;
        height: 1.8rem;
    }
}

/* Marqueur de pronostic */
.sepsis-marker {
    margin: 5rem 0;
    background: var(--background-light);
    padding: 4rem 2rem;
    border-radius: 20px;
}

.marker-diagram {
    position: relative;
    min-height: 500px;
    margin-top: 3rem;
}

.diagram-center {
    position: absolute;
    top: 50%;
    left: 50%;
    transform: translate(-50%, -50%);
    z-index: 2;
}

.icon-rbc-center {
    width: 120px;
    height: 120px;
    background: radial-gradient(circle, var(--primary-color) 0%, var(--primary-dark) 100%);
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    font-size: 3rem;
    box-shadow: 0 6px 20px rgba(196, 30, 58, 0.4);
    border: 4px solid white;
}

.diagram-points {
    position: relative;
    width: 100%;
    height: 100%;
}

.diagram-point {
    position: absolute;
    background: var(--background-white);
    border-radius: 20px;
    padding: 1.5rem;
    box-shadow: var(--shadow);
    max-width: 250px;
    border-top: 3px solid var(--accent-color);
}

.diagram-point.top-left {
    top: 0;
    left: 0;
}

.diagram-point.top-right {
    top: 0;
    right: 0;
}

.diagram-point.bottom-right {
    bottom: 0;
    right: 0;
}

.diagram-point.bottom-left {
    bottom: 0;
    left: 0;
}

.point-icon {
    margin-bottom: 0.5rem;
    display: flex;
    justify-content: center;
}

.icon-early,
.icon-correlation,
.icon-mortality,
.icon-monitoring {
    width: 50px;
    height: 50px;
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    font-size: 1.5rem;
    box-shadow: 0 2px 10px rgba(0, 0, 0, 0.1);
}

.icon-early,
.icon-correlation,
.icon-mortality,
.icon-monitoring {
    background: linear-gradient(135deg, var(--accent-color) 0%, #2980b9 100%);
}

.diagram-point p {
    font-size: 0.95rem;
    color: var(--text-dark);
    line-height: 1.6;
    margin: 0;
    text-align: center;
}

/* Proposition de valeur */
.sepsis-value {
    margin: 5rem 0;
}

.value-content {
    margin-top: 3rem;
}

.value-text {
    font-size: 1.2rem;
    color: var(--text-dark);
    line-height: 1.8;
    text-align: center;
    max-width: 900px;
    margin: 0 auto 3rem;
}

.value-diagram {
    position: relative;
    min-height: 400px;
    margin-top: 3rem;
}

.value-center {
    position: absolute;
    top: 50%;
    left: 50%;
    transform: translate(-50%, -50%);
    z-index: 2;
}

.icon-growth-center {
    width: 100px;
    height: 100px;
    background: linear-gradient(135deg, #2c3e50 0%, #34495e 100%);
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    font-size: 2.5rem;
    box-shadow: 0 6px 20px rgba(0, 0, 0, 0.3);
    border: 4px solid white;
}

.value-points {
    position: relative;
    width: 100%;
    height: 100%;
}

.value-point {
    position: absolute;
    text-align: center;
    max-width: 200px;
}

.value-point:nth-child(1) {
    top: 0;
    left: 50%;
    transform: translateX(-50%);
}

.value-point:nth-child(2) {
    top: 50%;
    right: 0;
    transform: translateY(-50%);
}

.value-point:nth-child(3) {
    bottom: 0;
    left: 50%;
    transform: translateX(-50%);
}

.value-point:nth-child(4) {
    top: 50%;
    left: 0;
    transform: translateY(-50%);
}

.value-icon {
    margin-bottom: 1rem;
    display: flex;
    justify-content: center;
}

.icon-innovation,
.icon-efficacy,
.icon-benefit,
.icon-costs {
    width: 60px;
    height: 60px;
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    font-size: 1.8rem;
    box-shadow: 0 4px 15px rgba(0, 0, 0, 0.2);
    border: 2px solid var(--accent-color);
}

.icon-innovation,
.icon-efficacy,
.icon-benefit,
.icon-costs {
    background: rgba(52, 152, 219, 0.1);
}

.value-point p {
    font-size: 0.9rem;
    color: var(--text-dark);
    font-weight: bold;
    line-height: 1.4;
    margin: 0;
}

/* Publications Sepsis */
.sepsis-publications {
    margin: 5rem 0;
}

.sepsis-publications .publications-list {
    display: flex;
    flex-direction: column;
    gap: 1.5rem;
    margin-top: 2rem;
}

.sepsis-publications .publication-item {
    background: var(--background-white);
    border-radius: 20px;
    padding: 2rem;
    box-shadow: var(--shadow);
    border-left: 4px solid var(--primary-color);
}

.sepsis-publications .publication-title {
    font-weight: bold;
    color: var(--text-dark);
    margin-bottom: 0.5rem;
    line-height: 1.5;
    font-size: 1.1rem;
}

.sepsis-publications .publication-doi {
    color: var(--accent-color);
    font-size: 0.9rem;
    margin-top: 0.5rem;
    font-family: 'Courier New', monospace;
}

/* Responsive pour la section Sepsis */
@media (max-width: 968px) {
    .stats-grid {
        grid-template-columns: repeat(2, 1fr);
    }

    .flow-branches {
        flex-direction: column;
        gap: 1.5rem;
    }

    .diagram-point {
        position: relative;
        max-width: 100%;
        margin-bottom: 1rem;
    }

    .marker-diagram {
        min-height: auto;
    }

    .diagram-center {
        position: relative;
        transform: none;
        margin: 2rem auto;
    }

    .value-diagram {
        min-height: auto;
    }

    .value-center {
        position: relative;
        transform: none;
        margin: 2rem auto;
    }

    .value-point {
        position: relative;
        margin: 1rem auto;
    }
}

@media (max-width: 768px) {
    .sepsis-intro h2 {
        font-size: 2rem;
    }

    .intro-subtitle {
        font-size: 1.1rem;
    }

    .stats-grid {
        grid-template-columns: 1fr;
    }

    .flow-item {
        min-width: 100%;
    }
}

/* Styles pour la section Drepanocytose */
.drepanocytose-intro {
    text-align: center;
    margin-bottom: 4rem;
}

.drepanocytose-intro h2 {
    font-size: 2.5rem;
    color: var(--primary-color);
    margin-bottom: 1rem;
}

/* Statistiques principales */
.drepanocytose-stats {
    margin: 4rem 0;
}

.stats-main {
    display: flex;
    justify-content: center;
    gap: 4rem;
    flex-wrap: wrap;
}

.stat-main-card {
    background: var(--background-white);
    border: 3px solid #2c3e50;
    border-radius: 20px;
    padding: 3rem 4rem;
    text-align: center;
    box-shadow: var(--shadow);
    transition: var(--transition);
    min-width: 300px;
}

/* Effets hover supprimés pour les cartes non-cliquables */

.stat-main-icon {
    margin-bottom: 1.5rem;
    display: flex;
    justify-content: center;
}

.icon-people-world,
.icon-baby {
    width: 80px;
    height: 80px;
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    font-size: 2.5rem;
    box-shadow: 0 4px 15px rgba(0, 0, 0, 0.2);
}

.icon-people-world {
    background: linear-gradient(135deg, #2c3e50 0%, #34495e 100%);
}

.icon-baby {
    background: linear-gradient(135deg, #2c3e50 0%, #34495e 100%);
}

.stat-main-value {
    font-size: 2.5rem;
    font-weight: bold;
    color: #2c3e50;
    margin-bottom: 0.5rem;
}

.stat-main-label {
    font-size: 1.1rem;
    color: #2c3e50;
    font-weight: 500;
    line-height: 1.4;
}

/* Carte du monde */
.drepanocytose-map {
    margin: 4rem 0;
}

.map-container {
    background: var(--background-white);
    border-radius: 20px;
    padding: 2rem;
    box-shadow: var(--shadow);
}

.map-placeholder {
    background: var(--background-light);
    border: 2px dashed var(--border-color);
    border-radius: 10px;
    padding: 4rem 2rem;
    min-height: 400px;
    display: flex;
    align-items: center;
    justify-content: center;
}

.map-label {
    text-align: center;
    color: var(--text-light);
    font-style: italic;
    font-size: 1.1rem;
}

/* Progression de la maladie */
.drepanocytose-progression {
    margin: 5rem 0;
    background: var(--background-light);
    padding: 4rem 2rem;
    border-radius: 20px;
}

.progression-flow {
    display: flex;
    flex-direction: column;
    align-items: center;
    gap: 1.5rem;
    margin-top: 3rem;
}

.progression-step {
    display: flex;
    align-items: center;
    gap: 2rem;
    background: var(--background-white);
    border-radius: 20px;
    padding: 2rem;
    box-shadow: var(--shadow);
    width: 100%;
    max-width: 700px;
    transition: var(--transition);
}

/* Effets hover supprimés pour les éléments non-cliquables */

.progression-icon {
    flex-shrink: 0;
}

.icon-dna,
.icon-sickle-cell,
.icon-lungs,
.icon-lifespan {
    width: 70px;
    height: 70px;
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    font-size: 2rem;
    box-shadow: 0 4px 15px rgba(0, 0, 0, 0.2);
}

.icon-dna {
    background: linear-gradient(135deg, var(--accent-color) 0%, #2980b9 100%);
}

.icon-sickle-cell {
    background: linear-gradient(135deg, #ff8c42 0%, #ff6b35 100%);
}

.icon-lungs {
    background: linear-gradient(135deg, #ff8c42 0%, #ff6b35 100%);
}

.icon-lifespan {
    background: linear-gradient(135deg, var(--accent-color) 0%, #2980b9 100%);
}

.progression-content {
    flex: 1;
}

.progression-content p:first-child {
    font-size: 1.2rem;
    font-weight: bold;
    color: var(--primary-color);
    margin-bottom: 0.5rem;
}

.progression-content p:last-child {
    font-size: 1rem;
    color: var(--text-dark);
    line-height: 1.6;
    margin: 0;
}

.progression-arrow {
    font-size: 2rem;
    color: var(--accent-color);
    font-weight: bold;
}

/* Crises vaso-occlusives */
.drepanocytose-crises {
    margin: 4rem 0;
}

.crises-box {
    background: linear-gradient(135deg, var(--primary-color) 0%, var(--primary-dark) 100%);
    border-radius: 20px;
    padding: 3rem;
    color: white;
    text-align: center;
    box-shadow: var(--shadow-hover);
}

.crises-box h3 {
    font-size: 2rem;
    margin-bottom: 1.5rem;
}

.crises-box p {
    font-size: 1.2rem;
    line-height: 1.8;
    opacity: 0.95;
}

/* Statistique AVC */
.drepanocytose-stroke {
    margin: 4rem 0;
}

.stroke-stat {
    display: flex;
    align-items: center;
    justify-content: center;
    gap: 3rem;
    background: var(--background-white);
    border-radius: 20px;
    padding: 3rem;
    box-shadow: var(--shadow);
}

.stroke-icon {
    flex-shrink: 0;
}

.icon-brain-stroke {
    width: 120px;
    height: 120px;
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    font-size: 3rem;
    background: linear-gradient(135deg, #ff8c42 0%, #ff6b35 100%);
    box-shadow: 0 6px 20px rgba(255, 140, 66, 0.3);
}

.stroke-content {
    text-align: left;
}

.stroke-value {
    font-size: 4rem;
    font-weight: bold;
    color: #2c3e50;
    margin-bottom: 0.5rem;
}

.stroke-content p {
    font-size: 1.3rem;
    color: #2c3e50;
    font-weight: bold;
    margin: 0;
}

/* Fardeau pour patients et société */
.drepanocytose-burden {
    margin: 5rem 0;
}

.burden-stats {
    display: flex;
    justify-content: center;
    gap: 2rem;
    flex-wrap: wrap;
    margin-top: 3rem;
}

.burden-stat-card {
    background: var(--background-white);
    border-radius: 20px;
    padding: 2.5rem 2rem;
    text-align: center;
    box-shadow: var(--shadow);
    transition: var(--transition);
    max-width: 300px;
    border-top: 4px solid var(--primary-color);
}

/* Effets hover supprimés pour les cartes non-cliquables */

.burden-icon {
    margin-bottom: 1.5rem;
    display: flex;
    justify-content: center;
}

.icon-frustration,
.icon-worry,
.icon-family {
    width: 80px;
    height: 80px;
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    font-size: 2rem;
    box-shadow: 0 4px 15px rgba(196, 30, 58, 0.2);
    border: 3px solid var(--primary-color);
    background: rgba(196, 30, 58, 0.1);
}

.burden-percentage {
    font-size: 3rem;
    font-weight: bold;
    color: var(--primary-color);
    margin-bottom: 1rem;
}

.burden-stat-card p {
    font-size: 1rem;
    color: var(--text-dark);
    line-height: 1.6;
    margin: 0;
    font-style: italic;
}

/* Coûts économiques */
.drepanocytose-costs {
    margin: 5rem 0;
    background: var(--background-light);
    padding: 4rem 2rem;
    border-radius: 20px;
}

.costs-grid {
    display: grid;
    grid-template-columns: repeat(2, 1fr);
    gap: 3rem;
    margin-top: 3rem;
}

.cost-card {
    background: var(--background-white);
    border-radius: 20px;
    padding: 3rem;
    text-align: center;
    box-shadow: var(--shadow);
    transition: var(--transition);
    border-top: 4px solid var(--primary-color);
}

/* Effets hover supprimés pour les cartes non-cliquables */

.cost-icon {
    margin-bottom: 1.5rem;
    display: flex;
    justify-content: center;
}

.icon-cost-2024,
.icon-cost-2030 {
    width: 80px;
    height: 80px;
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    font-size: 2rem;
    box-shadow: 0 4px 15px rgba(196, 30, 58, 0.2);
    background: linear-gradient(135deg, var(--primary-color) 0%, var(--primary-dark) 100%);
}

.cost-value {
    font-size: 2rem;
    font-weight: bold;
    color: var(--primary-color);
    margin-bottom: 1rem;
}

.cost-label {
    font-size: 1rem;
    color: var(--text-dark);
    line-height: 1.6;
}

/* Besoin clinique */
.drepanocytose-need {
    margin: 5rem 0;
}

.drepanocytose-need .need-box {
    background: var(--background-white);
    border-radius: 20px;
    padding: 3rem;
    box-shadow: var(--shadow);
    border-left: 4px solid var(--primary-color);
}

.need-text {
    font-size: 1.3rem;
    color: var(--text-dark);
    line-height: 1.8;
    margin-bottom: 2rem;
    text-align: center;
}

/* Proposition de valeur */
.drepanocytose-value {
    margin: 5rem 0;
}

.drepanocytose-value .value-content {
    margin-top: 2rem;
}

.drepanocytose-value .value-text {
    font-size: 1.2rem;
    color: var(--text-dark);
    line-height: 1.8;
    text-align: center;
    max-width: 900px;
    margin: 0 auto;
}

/* Responsive pour la section Drepanocytose */
@media (max-width: 968px) {
    .stats-main {
        flex-direction: column;
        align-items: center;
    }

    .progression-step {
        flex-direction: column;
        text-align: center;
    }

    .stroke-stat {
        flex-direction: column;
        text-align: center;
    }

    .stroke-content {
        text-align: center;
    }

    .costs-grid {
        grid-template-columns: 1fr;
    }

    .burden-stats {
        flex-direction: column;
        align-items: center;
    }
}

@media (max-width: 768px) {
    .drepanocytose-intro h2 {
        font-size: 2rem;
    }

    .stat-main-card {
        min-width: 100%;
        padding: 2rem;
    }

    .stroke-value {
        font-size: 3rem;
    }
}

/* Styles pour la page d'accueil */
.hero-section-home {
    background: linear-gradient(135deg, #f8f9fa 0%, #e9ecef 100%);
    color: var(--text-dark);
    min-height: 60vh;
}

.hero-content-home {
    text-align: center;
    max-width: 1000px;
    margin: 0 auto;
}

.hero-content-home h1 {
    font-size: 2.5rem;
    color: var(--primary-color);
    margin-bottom: 1.5rem;
    line-height: 1.3;
}

.hero-subtitle {
    font-size: 1.3rem;
    color: var(--text-dark);
    opacity: 0.9;
}

.about-section {
    background: var(--background-white);
    padding: 5rem 2rem;
}

.about-content {
    max-width: 900px;
    margin: 0 auto;
}

.about-text p {
    font-size: 1.1rem;
    line-height: 1.8;
    color: var(--text-dark);
    margin-bottom: 1.5rem;
    text-align: left;
}

.projects-section {
    background: var(--background-light);
    padding: 5rem 2rem;
}

.projects-grid {
    display: grid;
    grid-template-columns: repeat(2, 1fr);
    gap: 3rem;
    max-width: 1200px;
    margin: 3rem auto 0;
}

.project-card {
    background: var(--background-white);
    border-radius: 20px;
    padding: 3rem;
    text-align: center;
    box-shadow: var(--shadow);
    transition: var(--transition);
    border: 3px solid transparent;
}

/* Effets hover supprimés pour les cartes non-cliquables */

.project-drepanocytose {
    border-color: var(--primary-color);
}

.project-sepsis {
    border-color: #2c5f8d;
}

.project-icon {
    margin-bottom: 2rem;
    display: flex;
    justify-content: center;
}

.icon-project-drepanocytose,
.icon-project-sepsis {
    width: 100px;
    height: 100px;
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    font-size: 3rem;
    box-shadow: 0 6px 20px rgba(0, 0, 0, 0.15);
}

.icon-project-drepanocytose {
    background: linear-gradient(135deg, var(--primary-color) 0%, var(--primary-dark) 100%);
}

.icon-project-sepsis {
    background: linear-gradient(135deg, #2c5f8d 0%, #1e4263 100%);
}

.project-card h3 {
    font-size: 2rem;
    margin-bottom: 1.5rem;
    color: var(--text-dark);
}

.project-drepanocytose h3 {
    color: var(--primary-color);
}

.project-sepsis h3 {
    color: #2c5f8d;
}

.project-card p {
    font-size: 1.1rem;
    line-height: 1.7;
    color: var(--text-light);
    margin-bottom: 2rem;
}

.project-btn {
    display: inline-flex;
    align-items: center;
    justify-content: center;
    gap: 0.75rem;
    padding: 1.1rem 2.5rem;
    border-radius: 20px;
    text-decoration: none;
    font-weight: 600;
    transition: var(--transition);
    box-shadow: 0 6px 20px rgba(44, 95, 141, 0.3),
                0 2px 8px rgba(44, 95, 141, 0.2),
                inset 0 1px 0 rgba(255, 255, 255, 0.2);
    position: relative;
    overflow: hidden;
}

.project-btn::before {
    content: '';
    position: absolute;
    top: 0;
    left: -100%;
    width: 100%;
    height: 100%;
    background: linear-gradient(90deg, transparent, rgba(255, 255, 255, 0.3), transparent);
    transition: left 0.5s ease;
}

.project-btn:hover::before {
    left: 100%;
}

.btn-drepanocytose {
    background: linear-gradient(135deg, var(--primary-color) 0%, var(--primary-dark) 100%);
    color: white;
}

.btn-drepanocytose:hover {
    transform: translateY(-3px);
    box-shadow: 0 8px 28px rgba(44, 95, 141, 0.4),
                0 4px 12px rgba(44, 95, 141, 0.3),
                inset 0 1px 0 rgba(255, 255, 255, 0.3);
}

.btn-sepsis {
    background: linear-gradient(135deg, #2c5f8d 0%, #1e4263 100%);
    color: white;
}

.btn-sepsis:hover {
    transform: translateY(-3px);
    box-shadow: 0 8px 28px rgba(44, 95, 141, 0.4),
                0 4px 12px rgba(44, 95, 141, 0.3),
                inset 0 1px 0 rgba(255, 255, 255, 0.3);
}

@media (max-width: 768px) {
    .projects-grid {
        grid-template-columns: 1fr;
    }

    .hero-content-home h1 {
        font-size: 2rem;
    }
}

/* Styles pour la section Contact */
.contact-intro {
    text-align: center;
    margin-bottom: 4rem;
}

.contact-intro h2 {
    font-size: 2.5rem;
    color: var(--primary-color);
    margin-bottom: 1rem;
}

.contact-subtitle {
    font-size: 1.2rem;
    color: var(--text-dark);
    max-width: 700px;
    margin: 0 auto;
    line-height: 1.6;
}

.contact-content {
    display: grid;
    grid-template-columns: 1.5fr 1fr;
    gap: 4rem;
    max-width: 1200px;
    margin: 0 auto;
}

.contact-form-container {
    background: var(--background-white);
    border-radius: 20px;
    padding: 3rem;
    box-shadow: var(--shadow);
}

.contact-form-container h3 {
    font-size: 1.8rem;
    color: var(--primary-color);
    margin-bottom: 2rem;
}

.contact-form {
    display: flex;
    flex-direction: column;
    gap: 1.5rem;
}

.form-group {
    display: flex;
    flex-direction: column;
    gap: 0.5rem;
}

.form-group label {
    font-weight: 500;
    color: var(--text-dark);
    font-size: 1rem;
}

.form-group input,
.form-group textarea {
    padding: 1rem;
    border: 2px solid var(--border-color);
    border-radius: 16px;
    font-size: 1rem;
    font-family: inherit;
    transition: var(--transition);
    background: var(--background-light);
}

.form-group input:focus,
.form-group textarea:focus {
    outline: none;
    border-color: var(--primary-color);
    background: var(--background-white);
    box-shadow: 0 0 0 3px rgba(196, 30, 58, 0.1);
}

.form-group textarea {
    resize: vertical;
    min-height: 120px;
}

.submit-btn {
    padding: 1.1rem 2.5rem;
    background: linear-gradient(135deg, var(--primary-color) 0%, var(--primary-dark) 100%);
    color: white;
    border: none;
    border-radius: 16px;
    font-size: 1.1rem;
    font-weight: 600;
    cursor: pointer;
    transition: var(--transition);
    align-self: flex-start;
    box-shadow: 0 6px 20px rgba(44, 95, 141, 0.3), 
                0 2px 8px rgba(44, 95, 141, 0.2),
                inset 0 1px 0 rgba(255, 255, 255, 0.2);
    position: relative;
    overflow: hidden;
    display: inline-flex;
    align-items: center;
    justify-content: center;
    gap: 0.5rem;
}

.submit-btn::before {
    content: '';
    position: absolute;
    top: 0;
    left: -100%;
    width: 100%;
    height: 100%;
    background: linear-gradient(90deg, transparent, rgba(255, 255, 255, 0.3), transparent);
    transition: left 0.5s ease;
}

.submit-btn:hover::before {
    left: 100%;
}

.submit-btn:hover {
    transform: translateY(-3px);
    box-shadow: 0 8px 28px rgba(44, 95, 141, 0.4),
                0 4px 12px rgba(44, 95, 141, 0.3),
                inset 0 1px 0 rgba(255, 255, 255, 0.3);
    background: linear-gradient(135deg, var(--primary-dark) 0%, var(--primary-color) 100%);
}

.submit-btn:active {
    transform: translateY(-1px);
    box-shadow: 0 4px 16px rgba(44, 95, 141, 0.3);
}

.privacy-notice {
    font-size: 0.75rem;
    color: var(--text-light);
    margin-top: 1rem;
    line-height: 1.5;
    text-align: center;
    opacity: 0.8;
}

.contact-info {
    background: var(--background-white);
    border-radius: 20px;
    padding: 3rem;
    box-shadow: var(--shadow);
    height: fit-content;
}

.contact-info h3 {
    font-size: 1.8rem;
    color: var(--primary-color);
    margin-bottom: 2rem;
}

.info-item {
    display: flex;
    align-items: flex-start;
    gap: 1.5rem;
    margin-bottom: 2rem;
    padding-bottom: 2rem;
    border-bottom: 1px solid var(--border-color);
}

.info-item:last-child {
    border-bottom: none;
    margin-bottom: 0;
    padding-bottom: 0;
}

.info-icon {
    flex-shrink: 0;
}

.icon-email,
.icon-phone,
.icon-location {
    width: 50px;
    height: 50px;
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    font-size: 1.5rem;
    box-shadow: 0 4px 15px rgba(196, 30, 58, 0.2);
}

.icon-email {
    background: linear-gradient(135deg, var(--primary-color) 0%, var(--primary-dark) 100%);
}

.icon-phone {
    background: linear-gradient(135deg, var(--accent-color) 0%, #2980b9 100%);
}

.icon-location {
    background: linear-gradient(135deg, var(--primary-color) 0%, var(--primary-dark) 100%);
}

.info-content h4 {
    font-size: 1.1rem;
    color: var(--primary-color);
    margin-bottom: 0.5rem;
    font-weight: 600;
}

.info-content p {
    font-size: 1rem;
    color: var(--text-dark);
    line-height: 1.6;
    margin: 0;
}

/* Responsive pour la section Contact */
@media (max-width: 968px) {
    .contact-content {
        grid-template-columns: 1fr;
        gap: 3rem;
    }

    .contact-form-container,
    .contact-info {
        padding: 2rem;
    }
}

@media (max-width: 768px) {
    .contact-intro h2 {
        font-size: 2rem;
    }

    .contact-subtitle {
        font-size: 1rem;
    }

    .contact-form-container h3,
    .contact-info h3 {
        font-size: 1.5rem;
    }
}

/* ============================================
   FOOTER
   ============================================ */

.footer {
    background: linear-gradient(135deg, #1a1a1a 0%, #2d2d2d 100%);
    color: #e0e0e0;
    padding: 4rem 0 2rem;
    margin-top: 6rem;
    border-top: 3px solid var(--primary-color);
    position: relative;
    z-index: 10;
}

.footer-container {
    max-width: 1400px;
    margin: 0 auto;
    padding: 0 3rem;
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(250px, 1fr));
    gap: 3rem;
}

.footer-section {
    display: flex;
    flex-direction: column;
}

.footer-section h3 {
    color: #ffffff;
    font-size: 1.3rem;
    font-weight: 700;
    margin-bottom: 1.5rem;
    position: relative;
    padding-bottom: 0.8rem;
}

.footer-section h3::after {
    content: '';
    position: absolute;
    bottom: 0;
    left: 0;
    width: 50px;
    height: 3px;
    background: var(--primary-color);
    border-radius: 8px;
}

.footer-section p {
    line-height: 1.8;
    color: #b0b0b0;
    font-size: 0.95rem;
    margin: 0;
}

.footer-links {
    list-style: none;
    padding: 0;
    margin: 0;
}

.footer-links li {
    margin-bottom: 0.8rem;
}

.footer-links a {
    color: #b0b0b0;
    text-decoration: none;
    transition: all 0.3s ease;
    display: inline-block;
    font-size: 0.95rem;
    position: relative;
    padding-left: 0;
}

/* Flèche supprimée pour un design épuré */

.footer-links a:hover {
    color: #ffffff;
    transform: translateX(2px);
}

.footer-contact-info {
    display: flex;
    flex-direction: column;
    gap: 1rem;
}

.footer-contact-item {
    display: flex;
    align-items: flex-start;
    gap: 1rem;
}

.footer-contact-icon {
    flex-shrink: 0;
    width: 40px;
    height: 40px;
    background: rgba(196, 30, 58, 0.2);
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    color: var(--primary-color);
    font-size: 1.2rem;
}

.footer-contact-content {
    flex: 1;
}

.footer-contact-content strong {
    color: #ffffff;
    display: block;
    margin-bottom: 0.3rem;
    font-size: 0.9rem;
}

.footer-contact-content span {
    color: #b0b0b0;
    font-size: 0.9rem;
    line-height: 1.6;
}

.footer-social {
    display: flex;
    gap: 1rem;
    margin-top: 1rem;
}

.footer-social-link {
    width: 45px;
    height: 45px;
    background: rgba(255, 255, 255, 0.1);
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    color: #b0b0b0;
    text-decoration: none;
    transition: all 0.3s ease;
    font-size: 1.2rem;
    border: 2px solid transparent;
}

.footer-social-link:hover {
    background: var(--primary-color);
    color: #ffffff;
    transform: translateY(-3px);
    box-shadow: 0 5px 15px rgba(196, 30, 58, 0.4);
    border-color: var(--primary-color);
}

.footer-bottom {
    margin-top: 3rem;
    padding-top: 2rem;
    border-top: 1px solid rgba(255, 255, 255, 0.1);
    display: flex;
    justify-content: space-between;
    align-items: center;
    flex-wrap: wrap;
    gap: 1.5rem;
}

.footer-legal {
    display: flex;
    gap: 2rem;
    flex-wrap: wrap;
}

.footer-legal a {
    color: #b0b0b0;
    text-decoration: none;
    font-size: 0.85rem;
    transition: color 0.3s ease;
}

.footer-legal a:hover {
    color: var(--primary-color);
}

/* Système générique de cartes ouvrables */
.expandable-card {
    margin-bottom: 2rem;
}

.expandable-card:last-child {
    margin-bottom: 0;
}

.expandable-card-header {
    display: none; /* Masqué sur desktop */
}

.expandable-card-content {
    display: block; /* Toujours visible sur desktop */
}

/* Styles desktop pour les cartes */
.expandable-card-content {
    text-align: center;
}

/* Cartes ouvrables - Mobile: système de cartes */
@media (max-width: 768px) {
    .expandable-card {
        background: white;
        border-radius: 20px;
        border: 1px solid rgba(0, 0, 0, 0.1);
        box-shadow: 0 2px 8px rgba(0, 0, 0, 0.08);
        overflow: hidden;
        transition: all 0.3s ease;
        margin-bottom: 1rem;
    }
    
    .expandable-card-header {
        display: flex;
        width: 100%;
        justify-content: space-between;
        align-items: center;
        padding: 1rem 1.2rem;
        background: rgba(0, 0, 0, 0.03);
        border: none;
        cursor: pointer;
        text-align: left;
        font-size: 1rem;
        font-weight: 600;
        color: var(--text-dark);
        transition: all 0.3s ease;
    }
    
    .expandable-card-header:hover {
        background: rgba(0, 0, 0, 0.05);
    }
    
    .expandable-card-header:active {
        background: rgba(0, 0, 0, 0.08);
    }
    
    .expandable-card-title {
        flex: 1;
        font-weight: 600;
        color: var(--text-dark);
        line-height: 1.4;
    }
    
    .expandable-card-icon {
        font-size: 0.9rem;
        color: var(--text-dark);
        transition: transform 0.3s ease;
        margin-left: 0.5rem;
        flex-shrink: 0;
    }
    
    .expandable-card-header[aria-expanded="true"] .expandable-card-icon {
        transform: rotate(180deg);
    }
    
    .expandable-card-content {
        display: none;
        padding: 0;
        max-height: 0;
        overflow: hidden;
        transition: max-height 0.4s ease, padding 0.4s ease;
    }
    
    .expandable-card-header[aria-expanded="true"] + .expandable-card-content {
        display: block;
        padding: 1.2rem;
        max-height: 5000px;
    }
    
    .expandable-card-content p {
        font-size: 1rem;
        line-height: 1.7;
        margin: 0 0 1.5rem 0;
        text-align: left;
        color: var(--text-dark);
    }
    
    .expandable-card-content img {
        width: 100%;
        height: auto;
        border-radius: 16px;
        margin: 1rem 0;
    }
}

/* Flèches de scroll - Design amélioré et centré verticalement sur le côté, rassemblées - Bleu cohérent */
.scroll-arrow {
    position: fixed;
    z-index: 999;
    background: linear-gradient(135deg, #2c5f8d 0%, #1e4263 100%);
    color: white;
    width: 72px;
    height: 72px;
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    cursor: pointer;
    transition: all 0.3s cubic-bezier(0.4, 0, 0.2, 1);
    box-shadow: 0 8px 30px rgba(44, 95, 141, 0.5), 0 4px 12px rgba(0, 0, 0, 0.25);
    border: 3px solid rgba(255, 255, 255, 0.4);
    font-size: 2rem;
    font-weight: bold;
    text-decoration: none;
    user-select: none;
    right: 30px;
    transform: translateY(-50%);
}

.scroll-arrow:hover {
    background: linear-gradient(135deg, #1e4263 0%, #132839 100%);
    box-shadow: 0 10px 35px rgba(44, 95, 141, 0.6), 0 6px 16px rgba(0, 0, 0, 0.3);
    transform: translateY(-50%) translateY(-4px);
    border-color: rgba(255, 255, 255, 0.6);
    width: 76px;
    height: 76px;
}

.scroll-arrow:active {
    transform: translateY(-50%) translateY(-2px);
    box-shadow: 0 6px 24px rgba(44, 95, 141, 0.5), 0 3px 10px rgba(0, 0, 0, 0.2);
}

.scroll-arrow-down {
    top: calc(50% - 45px);
    right: 30px;
}

.scroll-arrow-bottom {
    top: calc(50% + 45px);
    right: 30px;
    bottom: auto;
    transform: translateY(-50%);
}

.scroll-arrow-bottom:active {
    transform: translateY(-50%) translateY(-2px);
}

.scroll-arrow-bottom.hidden {
    transform: translateY(-50%) scale(0.8);
}

.scroll-arrow.hidden {
    opacity: 0;
    visibility: hidden;
    pointer-events: none;
    transform: translateY(-50%) scale(0.8);
}

.scroll-arrow-bottom.hidden {
    transform: scale(0.8);
}

/* Bouton toggle pour afficher/masquer les flèches sur mobile - Bleu cohérent */
.scroll-arrows-toggle {
    display: none;
    position: fixed;
    bottom: 20px;
    right: 20px;
    z-index: 998;
    width: 50px;
    height: 50px;
    border-radius: 50%;
    background: linear-gradient(135deg, #2c5f8d 0%, #1e4263 100%);
    color: white;
    border: 2px solid rgba(255, 255, 255, 0.3);
    box-shadow: 0 6px 20px rgba(44, 95, 141, 0.4);
    cursor: pointer;
    font-size: 1.5rem;
    font-weight: bold;
    transition: all 0.3s ease;
    align-items: center;
    justify-content: center;
}

.scroll-arrows-toggle:hover {
    transform: scale(1.1);
    box-shadow: 0 8px 25px rgba(44, 95, 141, 0.5);
}

.scroll-arrows-hidden .scroll-arrow {
    opacity: 0;
    visibility: hidden;
    pointer-events: none;
    transform: translateY(-50%) scale(0.8);
}

.scroll-arrows-hidden .scroll-arrow-bottom {
    transform: translateY(-50%) scale(0.8);
}

@media (max-width: 768px) {
    .scroll-arrows-toggle {
        display: flex;
    }
    
    .scroll-arrow {
        width: 64px;
        height: 64px;
        font-size: 1.8rem;
        right: 20px;
    }
    
    .scroll-arrow:hover {
        width: 68px;
        height: 68px;
    }
    
    .scroll-arrow-down {
        top: calc(50% - 40px);
        right: 20px;
    }
    
    .scroll-arrow-bottom {
        top: calc(50% + 40px);
        right: 20px;
    }
    
    /* Masquer les flèches par défaut sur mobile */
    .scroll-arrow {
        opacity: 0;
        visibility: hidden;
        pointer-events: none;
        transform: translateY(-50%) scale(0.8);
    }
    
    .scroll-arrow-bottom {
        transform: translateY(-50%) scale(0.8);
    }
    
    /* Afficher les flèches quand la classe active est présente */
    body.scroll-arrows-visible .scroll-arrow {
        opacity: 1;
        visibility: visible;
        pointer-events: auto;
        transform: translateY(-50%);
    }
    
    body.scroll-arrows-visible .scroll-arrow-bottom {
        transform: translateY(-50%);
    }
}

@media (max-width: 480px) {
    .scroll-arrow {
        width: 58px;
        height: 58px;
        font-size: 1.6rem;
        right: 15px;
    }
    
    .scroll-arrow:hover {
        width: 62px;
        height: 62px;
    }
    
    .scroll-arrow-down {
        top: calc(50% - 36px);
        right: 15px;
    }
    
    .scroll-arrow-bottom {
        top: calc(50% + 36px);
        right: 15px;
    }
}

/* Amélioration pour très petits écrans */
@media (max-width: 480px) {
    .expandable-card-header {
        padding: 0.9rem 1rem;
        font-size: 0.95rem;
    }
    
    .expandable-card-content {
        padding: 1rem !important;
    }
    
    .expandable-card-content p {
        font-size: 0.95rem;
        line-height: 1.6;
    }
}

.footer-copyright {
    color: #888;
    font-size: 0.85rem;
    margin: 0;
}

/* Footer pour pages principales (bleu) */
.page-home .footer,
.page-sepsis .footer {
    border-top-color: #2c5f8d;
}

.page-home .footer-section h3::after,
.page-sepsis .footer-section h3::after {
    background: #2c5f8d;
}

.page-home .footer-links a::before,
.page-sepsis .footer-links a::before {
    color: #2c5f8d;
}

.page-home .footer-contact-icon,
.page-sepsis .footer-contact-icon {
    background: rgba(44, 95, 141, 0.2);
    color: #2c5f8d;
}

.page-home .footer-social-link:hover,
.page-sepsis .footer-social-link:hover {
    background: #2c5f8d;
    box-shadow: 0 5px 15px rgba(44, 95, 141, 0.4);
    border-color: #2c5f8d;
}

.page-home .footer-legal a:hover,
.page-sepsis .footer-legal a:hover {
    color: #2c5f8d;
}

/* Responsive Footer */
@media (max-width: 992px) {
    .footer-container {
        grid-template-columns: repeat(2, 1fr);
        gap: 2.5rem;
    }
}

@media (max-width: 768px) {
    .footer {
        padding: 3rem 0 1.5rem;
    }

    .footer-container {
        grid-template-columns: 1fr;
        gap: 2rem;
        padding: 0 2rem;
    }

    .footer-bottom {
        flex-direction: column;
        text-align: center;
        gap: 1rem;
    }

    .footer-legal {
        justify-content: center;
        gap: 1.5rem;
    }

    .footer-social {
        justify-content: center;
    }
}

@media (max-width: 480px) {
    .footer-container {
        padding: 0 1.5rem;
    }

    .footer-section h3 {
        font-size: 1.1rem;
    }

    .footer-social-link {
        width: 40px;
        height: 40px;
        font-size: 1rem;
    }
}