DYNARED — A Tool Serving Scientific Research

Red blood cell deformability: a key parameter for health

The advantages of DYNARED technology

(A) Typical images of layers of red blood cells from healthy blood samples (HbAA) and from patients with sickle cell disease (HbSS), after separation in discontinuous Percoll density gradients of increasing densities. (B–C) The transition to tank-treading motion (membrane rotation) is influenced by both cell density and sickle cell pathology. Percentages of red blood cells exhibiting tank-treading behavior (fTT) as a function of shear stress, in HbAA and HbSS samples, for layers L2 and L4 respectively.

fTT is sensitive to red blood cell density as well as to sickle cell disease

Frontiers in Physiology, 12, 2406 (2022). https ://doi.org/10.3389%2Ffphys.2021.775584