Red blood cell deformability: a clinical monitoring marker
SEPSIS

Red blood cell deformability: an early prognostic and severity biomarker in sepsis

The fTT value for patients with sepsis is significantly lower than that of controls.

The fTT marker is sensitive to the onset of Sepsis

ICOVELL‘s ambition is to improve patient survival by providing an early and predictive marker of sepsis severity

DYNARED: a technology for decentralized use in emergency departments or at the patient’s bedside (Point-of-Care)

  • Katia Donadello et al. Reduced red blood cell deformability over time is associated with a poor outcome on septic patients, Microvascular Research 2015, DOI: 10.1016/j.mvr.2015.05.001
  • A.G. Moutzouri et al. Red blood cell deformability in patients with sepsis: A marker for prognosis and monitoring of severity, Clin. Hemorheol. Microcirc. (2007), PMID: 17502699
SICKLE CELL DISEASE

fTT: A marker for a better care of sickle cell patients

The fTT marker allows for the discrimination of HbSS patients from HbAA (healthy controls) and HbAS (heterozygous/trait) patients.

It correlates with HbF (Fetal Hemoglobin), HbS (Sickle Hemoglobin), hemolysis markers, and inflammation markers.

fTT values for healthy controls (HbAA), heterozygous (HbAS), and homozygous (HbSS)

fTT, a marker to predict the short-term onset of vaso-occlusive crises

fTT correlates with parameters associated with Vaso-Occlusive Crises: red blood cell density and hydration, and patient pain.

Patients experiencing a Vaso-Occlusive Crisis have lower fTT values.

Each patient has a unique baseline fTT value that drops a few hours before the onset of a crisis.

Patients admitted to the hospital in crisis (CVO) have a significantly lower fTT than patients who are out of crisis (Autre).
  • A novel red blood cell deformability biomarker is associated with hemolysis and vaso-occlusive crises in sickle cell disease. M. Sahun, E. Bernit, S. Atwell, A. Hornung, A.M. Charrier, I. Agouti, N. Bonello-Palot,  M. Cerino, E. Helfer, C. Badens, A. Viallat, Scientific Reports 15, 15864 (2025). DOI: 10.1038/s41598-025-00152-w 
  • Dynamics of individual red blood cells under shear flow: a way to discriminate deformability alterations. Atwell, S., Badens, C., Charrier, A., Helfer, E., & Viallat, A. Frontiers in Physiology, 12, 2406 (2022). DOI: 10.3389/fphys.2021.775584